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Diagnostic and prognostic value of serum miR-9-5p and miR-128-3p levels in early-stage acute ischemic stroke
Wang, Qi; Wang, Fei; Fu, Fengwei; Liu, Jinlin; Sun, Weilu; Chen, Yongqing.
  • Wang, Qi; Beijing Rehabilitation Hospital of Capital Medical University. Neurorehabilitation Center. CN
  • Wang, Fei; Binzhou Hospital of Traditional Chinese Medicine. Department of Encephalopathy. Binzhou. CN
  • Fu, Fengwei; Gucheng County Hospital of Hebei Province. The Fifth Department of Internal Medicine. Hengshui. CN
  • Liu, Jinlin; Gucheng County Hospital of Hebei Province. Laboratory Department. Hengshui. CN
  • Sun, Weilu; Gaoqing County Peoples Hospital. Department of Neurology. Zibo. CN
  • Chen, Yongqing; Yantai Municipal Laiyang Central Hospital. Department of Neurology. Yantai. CN
Clinics ; 76: e2958, 2021. tab, graf
Article in English | LILACS | ID: biblio-1345819
ABSTRACT

OBJECTIVES:

To investigate the clinical utility of serum microRNA levels (miR-9-5p and miR-128-3p) in the diagnosis and prognosis of early-stage acute ischemic stroke (AIS).

METHODS:

We compared the differences in serum miR-9-5p and miR-128-3p levels between patients with AIS and healthy individuals (controls). The serum levels of miR-9-5p and miR-128-3p were quantified using quantitative real-time PCR, and the association of each miRNA with AIS was determined using receiver operator characteristic curve analysis. The predictive value of these indices in the diagnosis of early-stage AIS was evaluated in conjunction with that of computed tomography findings and neuron-specific enolase levels. The prognosis of patients with AIS was evaluated three months after their discharge from hospital using the modified Rankin scale, which classifies the prognosis as either favorable or poor. Logistic regression analysis was used to analyze the correlation between miR-9-5p and miR-128-3p levels and patient prognosis.

RESULTS:

The serum levels of miR-9-5p and miR-128-3p were upregulated in patients with AIS relative to those in healthy individuals. A pronounced correlation was identified between serum miR-9-5p and miR-128-3p levels and patient prognosis, with high levels of both miRNAs being associated with poor patient outcomes.

CONCLUSION:

Assessment of serum miR-9-5p and miR-128-3p levels is important for the early diagnosis and prognosis of AIS.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Brain Ischemia / MicroRNAs / Ischemic Stroke Type of study: Diagnostic study / Prognostic study / Screening study Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Beijing Rehabilitation Hospital of Capital Medical University/CN / Binzhou Hospital of Traditional Chinese Medicine/CN / Gaoqing County Peoples Hospital/CN / Gucheng County Hospital of Hebei Province/CN / Yantai Municipal Laiyang Central Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Brain Ischemia / MicroRNAs / Ischemic Stroke Type of study: Diagnostic study / Prognostic study / Screening study Limits: Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Beijing Rehabilitation Hospital of Capital Medical University/CN / Binzhou Hospital of Traditional Chinese Medicine/CN / Gaoqing County Peoples Hospital/CN / Gucheng County Hospital of Hebei Province/CN / Yantai Municipal Laiyang Central Hospital/CN