Predominant low Hematopoietic Cell Transplantation Specific Comorbidity Index (HCT-CI) score in a Mexican referral center: a selection bias caused by limited-resources?
Hematol., Transfus. Cell Ther. (Impr.)
; 43(3): 249-255, July-Sept. 2021. tab, graf
Article
in En
| LILACS
| ID: biblio-1346271
Responsible library:
BR408.1
Localization: BR408.1
ABSTRACT
Abstract Introduction:
To date, many studies have validated the Hematopoietic Cell Transplantation Specific Comorbidity Index (HCT-CI) scoring system in allogeneic hematopoietic stem cell transplantation (allo-HSCT), but studies from developing countries remain scarce.Objective:
The aim of this study was to evaluate and categorize Mexican patients using the HCT-CI at a referral center.Methods:
One hundred and nineteen consecutive patients undergoing allo-HSCT at the National Institute of Medical Sciences and Nutrition in Mexico City were included. Patients were classified according to the HCT-CI scores.Results:
The median age was 31 years and most were males (56%). Most patients had hematological malignancies (73%) and a low HCT-CI score (72%). The non-relapse mortality and survival were predicted according to the score.Conclusions:
This is one of the few studies to evaluate the HCT-CI in adults with HLA-matched donors in a developing country and our findings suggest that the high percentage of patients with a low HCT-CI scores, contrary to international reports, could be explained by different comorbidities and demographics, but mainly due to stricter filters applied to HSCT candidates and consequently, a potential selection bias caused by limited resources.Key words
Full text:
1
Index:
LILACS
Main subject:
Hematopoietic Stem Cell Transplantation
Type of study:
Prognostic_studies
Country/Region as subject:
Mexico
Language:
En
Journal:
Hematol., Transfus. Cell Ther. (Impr.)
Journal subject:
Hematologia
/
TransfusÆo de Sangue
Year:
2021
Type:
Article