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Prevalence of anal intraepithelial lesions in patients with inflammatory bowel disease
Savio, Mariane Christina; Baldin, Rosimeri Kuhl Svoboda; Nóbrega, Norton Luiz; Nicollelli, Guilherme Mattioli; Brenner, Antonio Sérgio; Rocha, Pollyanna Borges da; Rossoni, Marssoni Deconto; Sartor, Maria Cristina; Baldin Junior, Antonio.
  • Savio, Mariane Christina; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Baldin, Rosimeri Kuhl Svoboda; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Nóbrega, Norton Luiz; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Nicollelli, Guilherme Mattioli; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Brenner, Antonio Sérgio; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Rocha, Pollyanna Borges da; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Rossoni, Marssoni Deconto; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Sartor, Maria Cristina; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
  • Baldin Junior, Antonio; Universidade Federal do Paraná. Hospital de Clínicas. Coloproctology Service. Curitiba. BR
J. coloproctol. (Rio J., Impr.) ; 41(3): 222-227, July-Sept. 2021. tab
Article in English | LILACS | ID: biblio-1346422
ABSTRACT

Introduction:

Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal canal associated with HPV, with a higher prevalence in immunosuppressed individuals. Patients with inflammatory bowel disease (IBD) are at potential risk for their development, due to the use of immunosuppressants and certain characteristics of the disease.

Method:

This is a prospective, cross-sectional, and interventional study that included 53 patients with IBD treated at a tertiary outpatient clinic, who underwent anal smear for cytology in order to assess the prevalence of AIN and associated risk factors.

Results:

Forty-eight samples were negative for dysplasia and 2 were positive (4%). Both positive samples occurred in women, with Crohn's disease (CD), who were immunosuppressed and had a history of receptive anal intercourse.

Discussion:

The prevalence of anal dysplasia in IBD patients in this study is similar to that described in low-risk populations. Literature data are scarce and conflicting and there is no evidence to recommend screening with routine anal cytology in patients with IBD. Female gender, history of receptive anal intercourse, immunosuppression and CD seem to be risk factors. (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Anal Canal / Anus Neoplasms / Inflammatory Bowel Diseases Type of study: Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: J. coloproctol. (Rio J., Impr.) Journal subject: Cirurgia / Doen‡as Retais / Doen‡as do Colo / Gastroenterology / Cirurgia Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Anal Canal / Anus Neoplasms / Inflammatory Bowel Diseases Type of study: Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Language: English Journal: J. coloproctol. (Rio J., Impr.) Journal subject: Cirurgia / Doen‡as Retais / Doen‡as do Colo / Gastroenterology / Cirurgia Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR