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Clinical evolution of a severe asthmatics group in the use of immunobiological therapy in a Brazilian Public Hospital
Rabelo, Lêda Maria; Stival, Rebecca Saray Marchesini; Drevenowski, Diogo; Serafini, Joel; Leão, Giovanna Lemes; Ferreira, Matheus Fernando Rietter Quintino; Costa, Fabio Marcelo.
  • Rabelo, Lêda Maria; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
  • Stival, Rebecca Saray Marchesini; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
  • Drevenowski, Diogo; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
  • Serafini, Joel; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
  • Leão, Giovanna Lemes; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
  • Ferreira, Matheus Fernando Rietter Quintino; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
  • Costa, Fabio Marcelo; Universidade Federal do Paraná. Hospital de Clínicas. Curitiba. BR
Rev. Assoc. Med. Bras. (1992) ; 67(7): 931-936, July 2021. tab, graf
Article in English | LILACS | ID: biblio-1346935
ABSTRACT
SUMMARY

OBJECTIVE:

A small portion of the asthmatic population (3.6%) has severe asthma (SA), presenting high morbimortality rates and demanding more financial resources than other asthmatic populations. The use of immunobiological therapy is an effective tool in controlling symptoms, decreasing the number of exacerbations, and reducing the use of systemic corticosteroids in these patients. In Brazil, epidemiological data regarding this asthmatic population using immunobiologicals and their evolution are scarce.

METHODS:

This is an observational, analytical, cross-sectional, and retrospective study. The sample consisted of adult patients with SA in follow-up at the pulmonology service of the Complexo Hospital de Clínicas of the Federal University of Paraná, from January 2011 to August 2019. The analyzed variables were as follows the number of exacerbations that required hospitalization in the previous year, forced expiratory volume in one second (FEV1), and asthma control test (ACT) scores before and after the start of immunobiological therapy.

RESULTS:

We studied 20 patients with SA using omalizumab or mepolizumab. We observed an increase in the mean ACT score of 4.8 points, a nonsignificant reduction in the number of exacerbations that required hospitalization, and a slight improvement in the FEV1. Regarding the patients using chronic systemic corticosteroid therapy, 14.2% (n=1) of patients had the medication discontinued and 57% (n=4) of patients had the dose reduced by half.

CONCLUSION:

The use of omalizumab and mepolizumab as additional therapy in SA provided a significant improvement in the ACT and allowed the dose reduction of systemic corticosteroids, without significant improvement in FEV1 and in the frequency of severe exacerbations.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Asthma / Anti-Asthmatic Agents Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Asthma / Anti-Asthmatic Agents Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR