The impact of hydroxychloroquine and azithromycin on the corrected qt interval in patients with the novel Coronavirus disease 2019
Rev. Assoc. Med. Bras. (1992)
;
67(7): 979-984, July 2021. tab
Article
in English
| LILACS
| ID: biblio-1346946
ABSTRACT
SUMMARY OBJECTIVE:
With the coronavirus disease 2019 (COVID-19) continuing to spread all over the world, although there is no specific treatment until now, hydroxychloroquine and azithromycin have been reported to be effective in recent studies. Although long-term use of hydroxychloroquine and azithromycin has been reported to cause QT prolongation and malign arrhythmia, there is not enough data about the effect of short-term use on arrhythmia. Therefore, this study aims to assess the effect of hydroxychloroquine alone and hydroxychloroquine + azithromycin on corrected QT (QTc).METHODS:
A baseline electrocardiogram and on-treatment baseline electrocardiogram were retrospectively collected in COVID-19 patients who received hydroxychloroquine and/or azithromycin. The QTc interval was calculated, and the baseline and peak QTc intervals were compared. In addition, the peak QTc intervals of monotherapy and combination therapy were compared.RESULTS:
Of the 155 patients included, 102 (65.8%) patients were using hydroxychloroquine, and 53 (34.2%) patients were using hydroxychloroquine + azithromycin combination. The use of both hydroxychloroquine alone and hydroxychloroquine + azithromycin combined therapy significantly prolonged the QTc, and the QTc interval was significantly longer in patients receiving combination therapy. QTc prolongation caused early termination in both groups, 5 (4.9%) patients in the monotherapy group and 6 (11.3%) patients in the combination therapy group.CONCLUSION:
In this study, patients who received hydroxychloroquine for the treatment of COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc.
Full text:
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Index:
LILACS (Americas)
Main subject:
COVID-19
/
Hydroxychloroquine
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2021
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Eskisehir City Hospital/TR
/
Eskisehir Osmangazi University/TR
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