Comparison of nonspecific inflammatory markers in endometrial cancer and hyperplasia
Rev. Assoc. Med. Bras. (1992)
;
67(7): 966-970, July 2021. tab
Article
in English
| LILACS
| ID: biblio-1346961
ABSTRACT
SUMMARY OBJECTIVE:
This study aims to analyze inflammatory markers among patients with endometrial cancer, hyperplasia with atypia/endometrial intraepithelial neoplasia, hyperplasia without atypia, and normal controls, thus observing the stage at which inflammation becomes the most significant.METHODS:
A total of 444 patients who had endometrial sampling were included in the study (endometrial cancer, n=79; endometrial hyperplasia with atypia/endometrial intraepithelial neoplasia, n=27; endometrial hyperplasia without atypia, n=238; and normal controls, n=100). Neutrophil count, lymphocyte count, platelet count, platelet distribution width, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, CA-125, and endometrial thickness of the patients were recorded.RESULTS:
Comparing the groups for neutrophil count, the hyperplasia with atypia group had higher values compared with both the hyperplasia without atypia group and the control group (p=0.003). When compared for the lymphocyte count, the hyperplasia with atypia group had lower values compared with the control group (p=0.014). Neutrophil/lymphocyte ratio of the hyperplasia with atypia group was higher than all other groups, and neutrophil/lymphocyte ratio of the cancer group was higher than the control group (p=0.001). Platelet count, mean platelet volume, platelet distribution width, and platelet/lymphocyte ratio values were not significantly different among groups (p>0.05).CONCLUSIONS:
Considering the inflammatory markers, the most prominent result was that the hyperplasia with atypia group had neutrophilia, lymphopenia, and increased neutrophil/lymphocyte ratio compared with other groups.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Endometrial Neoplasms
/
Endometrial Hyperplasia
Type of study:
Observational study
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2021
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
University of Health Sciences/TR
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