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Vitamin D in patients with Hashimoto's disease: a systematic review and meta-analysis
dos Santos, Josiane Marlei Muller Fernandes; Alencar, Erika Vaz; Martins, Elisa Caroline de Oliveira; Ossoski, Cíntia Aparecida; Bonetti, Aline F.
  • dos Santos, Josiane Marlei Muller Fernandes; Programa de Pós-graduação em Ciências Farmacêuticas. Universidade Federal do Paraná (UFPR). Curitiba. BR
  • Alencar, Erika Vaz; Programa de Pós-graduação em Farmácia Clínica. Faculdades Pequeno Príncipe. Curitiba. BR
  • Martins, Elisa Caroline de Oliveira; Programa de Pós-graduação em Farmácia Clínica. Faculdades Pequeno Príncipe. Curitiba. BR
  • Ossoski, Cíntia Aparecida; Programa de Pós-graduação em Farmácia Clínica. Faculdades Pequeno Príncipe. Curitiba. BR
  • Bonetti, Aline F; Programa de Pós-graduação em Ciências Farmacêuticas. Universidade Federal do Paraná (UFPR). Curitiba. BR
Rev. ciênc. farm. básica apl ; 43: 1-13, 20220101.
Article in English | LILACS-Express | LILACS | ID: biblio-1348157
ABSTRACT
One of the most common thyroid dysfunctions is Hashimoto's disease (HD), characterized by the production of specific antibodies against thyroid gland antigens (Anti-Tg and Anti-TPO). Recent studies have suggested that vitamin D supplementation, associated with levothyroxine, may contribute to the control of this autoimmune disease. However, secondary studies on this topic, such as systematic reviews and meta-analyses, are still scarce. Thus, the present study aimed to evaluate the efficacy and safety of vitamin D in patients with HD through a systematic review with meta-analysis. Randomized clinical trials were selected on the Pubmed, Scopus, and Web of Science databases. Studies comparing groups of HD patients supplemented with vitamin D and non-supplemented HD patients were included. The following outcomes were considered TSH, T3, T4, Anti-Tg, Anti-TPO, and adverse drug reactions. The risk of bias was performed according to the Cochrane recommendations (RoB v. 2.0), and the quality of evidence was evaluated by the GRADE system. A total of 766 studies were identified in the databases, of which 7 met the eligibility criteria. None of the studies indicated the occurrence of adverse reactions with vitamin D supplementation in any administered dosage. Supplemented patients had a significant reduction in serum TSH levels compared to the control group (mean difference = -0.180 (95% CI [-0.316 to -0.045]), p = 0.009), suggesting that thyroid function was more controlled in the intervention group. However, for the other outcomes, no statistically significant differences were observed between the groups. Additionally, most of included articles (n=5/7) had some concerns or high risk of bias, and the quality of evidence revealed a moderate confidence for almost all outcomes; so the results must be interpreted with caution. Thus, more consistent, and robust clinical trials need to be carried out to confirm the efficacy of vitamin D supplementation in patients with HD.


Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial / Practice guideline / Prognostic study / Systematic reviews Language: English Journal: Rev. ciênc. farm. básica apl Journal subject: Pharmacology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Programa de Pós-graduação em Ciências Farmacêuticas/BR / Programa de Pós-graduação em Farmácia Clínica/BR

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Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial / Practice guideline / Prognostic study / Systematic reviews Language: English Journal: Rev. ciênc. farm. básica apl Journal subject: Pharmacology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Programa de Pós-graduação em Ciências Farmacêuticas/BR / Programa de Pós-graduação em Farmácia Clínica/BR