Tamarind seed polysaccharide (TSP) uses in ophthalmic drug delivery
Rev. ciênc. farm. básica apl
;
43: 1-10, 20220101.
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1349119
ABSTRACT
At present, ophthalmic drug delivery remains a major challenge, given the eye's protective structure and susceptibility to irritation, resulting in poor patient adherence. In order to overcome these constraints, new formulations are continually being developed. The inclusion of Galactoxyloglucan (Tamarind seed polysaccharide (TSP) in such formulations, a natural substance extracted from the seeds of Tamarindus indica, has shown great potential due to its physicochemical properties, high biocompatibility and safety profile. Such properties, have led to its use in formulations for the treatment of dry eye disease, glaucoma, and bacterial keratitis, as well as in dilating eye drops used in eye examinations. In this article, we highlight the most recent TSPbased ophthalmologic formulations, which indicate that this polymer is a strong candidate to reduce adverse effects, improve patient tolerability and drug bioavailability.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Rev. ciênc. farm. básica apl
Journal subject:
Pharmacology
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Department of Pharmaceutical Products/BR
/
Research and Development Department/BR
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