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Oral ID® as an adjunctive tool for surgical margin assessment in patients with oral squamous cell carcinoma: a comparative study / Oral ID® como uma ferramenta adjuvante para avaliação da margem cirúrgica em pacientes com carcinoma oral de células escamosas: um estudo comparativo
Mohamed, Yasmeen A; Mohammed, Sawsan A; Sulaiman, Ahmed M.
  • Mohamed, Yasmeen A; Karary University. Faculty of Dentistry. Department of Oral Pathology. Khartoum. SD
  • Mohammed, Sawsan A; University of Khartoum. Soba Hospital. Department of Oral and Maxillofacial Surgery. Khartoum. SD
  • Sulaiman, Ahmed M; University of Khartoum. Faculty of Dentistry. Department of Oral and Maxillofacial Surgery. Khartoum. SD
Braz. dent. sci ; 24(4, suppl 1): 1-12, 2021. tab, ilus, graf
Article in English | LILACS, BBO | ID: biblio-1349301
ABSTRACT

Objective:

The condition of the resected margin in oral squamous cell carcinoma continues to be an important prognostic factor; the use of optic technology could help surgeons in determining the margin status at real time. This study aims to evaluate Oral ID, a hand held device that uses the principal of auto-fluorescence to determine surgical safe margins in patients with oral squamous cell carcinoma, and to compare the results with those of the conventional 1 cm margin method. Material and

Methods:

This study was a descriptive, comparative analytical study carried out at Khartoum Dental Teaching Hospital and Oral Histopathology Diagnostic Laboratory, Faculty of Dentistry, University of Khartoum. A total of 92 margins obtained from 31 patients, 46 margins were taken by Oral ID and the other 46 were taken by the traditional 1cm method. All margins were examined histologically with conventional Hematoxylin and Eosin stain.

Results:

It was found that all tumors showed fluorescence loss; A significant association was found between the use of Oral ID and obtaining a free margin P (0.02) the sensitivity of Oral ID was found to be 74% the specificity was found to be 89%. Ten out of the 46 margins obtained by fluorescence showed mild dysplasia and two margins showed high grade dysplasia. The 46 margins obtained by the traditional 1cm margin showed different field alterations two were involved, one was close, five showed high grade dysplasia and 14 showed mild dysplasia yielding a specificity of 52.2%.

Conclusion:

Using Oral ID for surgical margin assessment increases the accuracy to 74% compared to the conventional method which was found to be 52.2%. The results of the device are comparable to other auto-fluorescence devices of different trademarks. Further development of the device to help overcome its limitations is strongly advised (AU)
RESUMO

Objetivo:

A condição da margem ressecada no carcinoma oral de células escamosas continua sendo um importante fator prognóstico; o uso de tecnologia óptica pode ajudar cirurgiões a determinar o status da margem em tempo real. O objetivo deste estudo é avaliar o Oral ID, um aparelho portátil que utiliza o princípio da autofluorescência para determinar margens de segurança cirúrgicas em pacientes com carcinoma oral de células escamosas, e comparar os resultados com o método convencional de margem de 1 cm. Material e

Métodos:

Este estudo foi um estudo descritivo, analítico e comparativo realizado no Khartoum Dental Teaching Hospital e no Laboratório de Diagnóstico de Histopatologia Oral da Faculdade de Odontologia, Universidade de Khartoum. Um total de 92 margens foram obtidas de 31 pacientes, 46 margens foram obtidas por Oral ID e as outras 46 foram obtidas pelo método tradicional de 1 cm. Todas as margens foram examinadas histologicamente com coloração convencional de Hematoxilina e Eosina.

Resultados:

Verificou-se que todos os tumores apresentaram perda de fluorescência; uma associação significativa foi encontrada entre o uso de Oral ID e a obtenção de uma margem livre P (0,02), a sensibilidade de Oral ID foi de 74% e a especificidade de 89%. Dez das 46 margens obtidas por fluorescência mostraram displasia leve e duas margens mostraram displasia de alto grau. As 46 margens obtidas pela margem tradicional de 1cm apresentaram diferentes alterações de campo, duas estavam envolvidas, uma estava próxima, cinco apresentaram displasia de alto grau e 14 apresentaram displasia leve com especificidade de 52,2%.

Conclusão:

O uso de Oral ID para avaliação da margem cirúrgica aumenta a acurácia para 74% em comparação com o método convencional, que foi encontrado em 52,2%. Os resultados do dispositivo são comparáveis a outros dispositivos de autofluorescência de diferentes marcas comerciais. O desenvolvimento do dispositivo para ajudar a superar suas limitações é fortemente recomendado. (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Diagnosis / Optical Imaging / Squamous Cell Carcinoma of Head and Neck / Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Braz. dent. sci Journal subject: Dentistry / Sa£de Bucal Year: 2021 Type: Article Affiliation country: Sudan Institution/Affiliation country: Karary University/SD / University of Khartoum/SD

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Full text: Available Index: LILACS (Americas) Main subject: Diagnosis / Optical Imaging / Squamous Cell Carcinoma of Head and Neck / Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Braz. dent. sci Journal subject: Dentistry / Sa£de Bucal Year: 2021 Type: Article Affiliation country: Sudan Institution/Affiliation country: Karary University/SD / University of Khartoum/SD