Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats
Acta cir. bras
;
36(11): e361105, 2021. tab, graf
Article
in English
| LILACS, VETINDEX
| ID: biblio-1349871
ABSTRACT
ABSTRACT Purpose:
The development of cutting surface leakage and postoperative peritoneal adhesions (PPA) after sleeve gastrectomy (SG) are the most serious operative complications. We investigated the effectiveness of the newly developed glycerol and sodium pentaborate containing formulation on the prevention of these complications.Methods:
Sixteen Sprague Dawley rats (mean weight 310 ± 50 g, mean age 3 months old) were divided into two groups, consisting of eight rats in each. SG and a double-layer suture technique were performed for each group. In study group, there was the mixture of 2 mL 3% glycerol plus 3% sodium pentaborate formulation, and in the control group 2 mL 0.9% NaCl was injected into the peritoneal cavity. Rats were sacrificed after 30 days, then macroscopic adhesion grade scoring and histopathological evaluations were assessed.Results:
Macroscopic PPA scores in the control and study groups were 2.75 ± 0.16 and 1.50 ± 0.327, respectively (p = 0.004). Histopatologic fibrosis scores in the control and study groups were 0.87 ± 0.125 and 2.00 ± 0.26, respectively (p = 0.002).Conclusions:
In SG operation model, glycerol plus sodium pentaborate compound decreased PPA formation and also increased stomach cut surface line fibrosis. This new formulation is hopeful for more safe SG operations.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Gastrectomy
/
Glycerol
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Year:
2021
Type:
Article
Institution/Affiliation country:
Marmara University Pendik Training and Research Hospital/TR
/
Yeditepe University Faculty of Medicine/TR
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