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Pregnancy has no significant impact on the prognosis of differentiated thyroid cancer
Nobre, Gabriela Maia; Tramontin, Mariana Yoshii; Treistman, Natalia; Alves Junior, Paulo Alonso; Andrade, Fernanda Accioly; Bulzico, Daniel Alves; Corbo, Rossana; Vaisman, Fernanda.
  • Nobre, Gabriela Maia; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Tramontin, Mariana Yoshii; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Treistman, Natalia; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Alves Junior, Paulo Alonso; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Andrade, Fernanda Accioly; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Bulzico, Daniel Alves; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Corbo, Rossana; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
  • Vaisman, Fernanda; Instituto Nacional do Câncer. Serviço de Oncologia Endócrina. Rio de Janeiro. BR
Arch. endocrinol. metab. (Online) ; 65(6): 768-777, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1349988
ABSTRACT
ABSTRACT

Objective:

To evaluate the impact of pregnancy on differentiated thyroid carcinomas (DTC) behavior Subjects and

methods:

Retrospective study of patients diagnosed with DTC before or during pregnancy and treated with standard therapy. In women diagnosed with DTC before pregnancy, we evaluated the occurrence of progression according to categories of response to therapy based on imaging and non-stimulated thyroglobulin (TG) levels.

Results:

Of 96 analyzed patients, 76 became pregnant after DTC treatment and 20 were diagnosed with DTC during pregnancy. Among women who became pregnant after a DTC diagnosis, no difference was observed regarding response to therapy before and after pregnancy. Disease progression after pregnancy was documented in six of these patients, while seven of them presented progression before pregnancy but were only treated after delivery. Patients with DTC diagnosed during pregnancy had a higher rate of distant metastases at diagnosis (30%) compared with the patients who became pregnant after DTC diagnosis (9.2%, p = 0.01).

Conclusion:

Pregnancy had no impact on the natural course of DTC. Disease progression after pregnancy was limited and probably related to more aggressive disease and higher risk stratification at diagnosis. Still, mild disease progression may have occurred asymptomatically in some patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Thyroidectomy / Thyroid Neoplasms Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Nacional do Câncer/BR

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Full text: Available Index: LILACS (Americas) Main subject: Thyroidectomy / Thyroid Neoplasms Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Nacional do Câncer/BR