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Dysfunctional eating behavior in fibromyalgia and its association with serum biomarkers of brain plasticity (BDNF and S100B): an exploratory study
Elkfury, Jéssica Lorenzzi; Antunes, Luciana C; Angoleri, Letícia dal Moro; Sipmann, Raquel Busanello; de Souza, Andressa; da Silva Torres, Iraci Lucena; Caumo, Wolnei.
  • Elkfury, Jéssica Lorenzzi; Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. Porto Alegre. BR
  • Antunes, Luciana C; Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. Porto Alegre. BR
  • Angoleri, Letícia dal Moro; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre. BR
  • Sipmann, Raquel Busanello; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre. BR
  • de Souza, Andressa; Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Ciências Biológicas. Farmacologia e Terapêutica. Canoas. BR
  • da Silva Torres, Iraci Lucena; Universidade Federal do Rio Grande do Sul. Laboratório de Dor e Neuromodulação. Porto Alegre. BR
  • Caumo, Wolnei; Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Ciências Médicas. Faculdade de Medicina. Porto Alegre. BR
Arch. endocrinol. metab. (Online) ; 65(6): 713-722, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1349991
ABSTRACT
ABSTRACT

Objectives:

To assess disordered eating, hunger and satiety perceptions in women with fibromyalgia (FM) compared to healthy controls (HC) and their association with biomarkers of brain plasticity (brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100B)). Subjects and

methods:

Cross-sectional exploratory study. The sample included FM (n = 20) and HC (n = 19), matched to age and waist perimeter. Dysfunctional eating was assessed through the Three Factor Eating Questionnaire and Eating Disorders Examination with a questionnaire. Hunger and satiety levels were rated by a Numerical Scale. Serum leptin, S100B and BDNF were analyzed.

Results:

The MANCOVA analysis showed that the mean of Emotional Eating rates was 30.65% higher in FM compared to HC ( p = 0.015). Eating, shape and weight concerns were 77.77%, 57.14% and 52.22% higher in FM ( p = <0.001) compared to HC, respectively. Moreover, the FM group reported higher scores for feeling of hunger "[5.2 (±2.9) vs. 4.8 (±2.0); p = 0.042] and lower scores for satiety [7.0 (±1.7) vs . 8.3 (±1.0); p = 0.038]. In the FM group, serum BDNF was negatively associated with hunger (r = - 0.52; p = 0.02), while S100B was positively associated with hunger scores (r = 0.463; p = 0.004).

Conclusion:

The present findings support the hypothesis that the association between FM and obesity can be mediated by a hedonistic pathway. Further research is needed.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Fibromyalgia / Brain-Derived Neurotrophic Factor Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Sul/BR / Universidade Federal do Rio Grande do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Fibromyalgia / Brain-Derived Neurotrophic Factor Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Sul/BR / Universidade Federal do Rio Grande do Sul/BR