Your browser doesn't support javascript.
loading
Incidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Benseñor, Isabela M; Janovsky, Carolina Castro Porto Silva; Goulart, Alessandra C; Santos, Itamar de Souza; Diniz, Maria de Fátima Haueisen Sander; Almeida-Pititto, Bianca de; Sgarbi, José Augusto; Lotufo, Paulo A.
  • Benseñor, Isabela M; Universidade de São Paulo. Divisão de Clínica Médica. Hospital Universitário. São Paulo. BR
  • Janovsky, Carolina Castro Porto Silva; Universidade de São Paulo. Divisão de Clínica Médica. Hospital Universitário. São Paulo. BR
  • Goulart, Alessandra C; Universidade de São Paulo. Divisão de Clínica Médica. Hospital Universitário. São Paulo. BR
  • Santos, Itamar de Souza; Universidade de São Paulo. Divisão de Clínica Médica. Hospital Universitário. São Paulo. BR
  • Diniz, Maria de Fátima Haueisen Sander; Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte. BR
  • Almeida-Pititto, Bianca de; Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo. BR
  • Sgarbi, José Augusto; Faculdade de Medicina de Marília. Departamento de Medicina. Divisão de Endocrinologia e Metabolismo. Marília. BR
  • Lotufo, Paulo A; Universidade de São Paulo. Divisão de Clínica Médica. Hospital Universitário. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 65(6): 832-840, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1350004
ABSTRACT
ABSTRACT

Objective:

Although some previous data have suggested a high iodine intake in Brazil, the prevalence of antithyroperoxidase antibodies (TPOAb) in the country is compatible with rates from countries with adequate iodine intake. This observation emphasizes the importance of knowing the incidence of TPOAb in Brazil. Materials and

methods:

This prospective analysis included euthyroid participants with negative TPOAb at baseline and a thyroid function assessment at a 4-year follow-up. TPOAb was measured by electrochemiluminescence and considered positive when titers were ≥34 IU/mL. TSH and free T4 (FT4) levels were determined by a third-generation immunoenzymatic assay. The incidence of TPOAb is expressed in percentage per year or as a cumulative incidence within the 4-year follow-up period.

Results:

Of 8,922 euthyroid participants (mean age 51.1 years; 50.9% women) with a negative TPOAb test at baseline, 130 presented incident TPOAb at the 4-year follow-up, yielding an annual incidence of TPOAb of 0.38%/year (95% confidence interval [95% CI], 0.37-0.39%/year) and a cumulative incidence over 4 years of 1.46% (95% CI, 1.21-1.71%). In men, the annual incidence was 0.32% (95% CI, 0.31-0.33%), and the cumulative incidence over 4 years was 1.23% (95% CI, 0.90-1.56%). In women, the annual incidence was 0.43%/year (95% CI, 0.42-0.44%/year) and the cumulative incidence over 4 years was 1.67% (95% CI, 1.30-2.04%). The only factor associated with incident TPOAb was the occurrence of thyroid diseases at follow-up. No differences in TPOAb incidence were detected across ELSA-Brasil research centers.

Conclusion:

Based on the results of this study, the incidence of TPOAb per year and at a 4-year follow-up period are compatible with those of a country with adequate iodine intake.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Iodide Peroxidase Type of study: Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina de Marília/BR / Universidade Federal de Minas Gerais/BR / Universidade de São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Iodide Peroxidase Type of study: Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina de Marília/BR / Universidade Federal de Minas Gerais/BR / Universidade de São Paulo/BR