Your browser doesn't support javascript.
loading
Hepatitis E virus infection increases the risk of diabetes and severity of liver disease in patients with chronic hepatitis C virus infection
Zitelli, Patricia Momoyo Yoshimura; Gomes-Gouvêa, Michele; Mazo, Daniel F.; Singer, Julio da Motta; Oliveira, Claudia P.M.S.; Farias, Alberto Queiroz; Pinho, João Renato; Tanigawa, Ryan Yukimatsu; Alves, Venâncio Avancini Ferreira; Carrilho, Flair José; Pessoa, Mário Guimarães.
  • Zitelli, Patricia Momoyo Yoshimura; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Gomes-Gouvêa, Michele; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Mazo, Daniel F.; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Singer, Julio da Motta; Universidade de Sao Paulo. Instituto de Matematica e Estatistica. Departamento de Estatistica. Sao Paulo. BR
  • Oliveira, Claudia P.M.S.; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Farias, Alberto Queiroz; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Pinho, João Renato; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Tanigawa, Ryan Yukimatsu; Universidade de Sao Paulo. Faculdade de Medicina FMUSP. Departamento de Patologia. Sao Paulo. BR
  • Alves, Venâncio Avancini Ferreira; Universidade de Sao Paulo. Faculdade de Medicina FMUSP. Departamento de Patologia. Sao Paulo. BR
  • Carrilho, Flair José; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Pessoa, Mário Guimarães; Universidade de Sao Paulo. Faculdade de Medicina. Divisao de Gastroenterologia e Hepatologia Clinica, Departamento de Gastroenterologia, Hospital das Clinicas HCFMUSP. Sao Paulo. BR
Clinics ; 76: e3270, 2021. tab, graf
Article in English | LILACS | ID: biblio-1350629
ABSTRACT

OBJECTIVES:

Co-infection with hepatitis A or B viruses may aggravate liver injury in patients infected with hepatitis C virus (HCV). However, few studies have assessed co-infection with hepatitis E virus (HEV) and HCV. Therefore, this study aimed to assess the prevalence and impact of HEV infection among Brazilian patients with chronic HCV infection.

METHODS:

This observational study included adult patients with chronic HCV infection who were naive to antiviral therapy from January 2013 to March 2016. A total of 181 patients were enrolled, and HEV serology and PCR were performed for all patients.

RESULTS:

Seropositivity for anti-HEV IgG was detected in 22 (12.0%) patients and anti-HEV immunoglobulin M in 3 (1.6%). HEV RNA showed inconclusive results in nine (4.9%) patients and was undetectable in the remaining patients. HEV serology positive patients had more severe liver disease, characterized by liver fibrosis ≥3 versus ≤2 (p<0.001), Aspartate Aminotransferase-to-Platelet Ratio Index of ≥1.45 (p=0.003), and Fibrosis-4 score of ≥3.25 (p=0.001). Additionally, the odds of HEV-positive patients developing diabetes mellitus were 3.65 (95% CI 1.40-9.52) times the corresponding odds of HEV-negative patients. A case-control-based histological analysis (n=11 HEV-HCV-positive patients and n=22 HCV-positive patients) showed no significant differences between the groups.

CONCLUSIONS:

This prevalence is higher than that reported in previous studies of the general population in Brazil. Thus, HEV infection may influence the severity of liver disease and may represent an additional risk of developing diabetes mellitus in patients with HCV infection.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Hepatitis E virus / Hepatitis E / Hepatitis C / Hepatitis C, Chronic / Diabetes Mellitus / Coinfection Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Hepatitis E virus / Hepatitis E / Hepatitis C / Hepatitis C, Chronic / Diabetes Mellitus / Coinfection Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR