Role of mean platelet volume in differential diagnosis of adult-onset Still's disease and sepsis
Rev. Assoc. Med. Bras. (1992)
;
67(10): 1443-1447, Oct. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1351442
ABSTRACT
SUMMARY OBJECTIVES:
Mean platelet volume is a simple biomarker for inflammatory disease. The purpose of this study is to evaluate the role of mean platelet volume in distinguishing adult-onset Still's disease from sepsis.METHODS:
We retrospectively selected 68 patients with adult-onset Still's disease and 55 patients with sepsis between January 2015 and December 2019. Related laboratory data were collected and analyzed.RESULTS:
There were no significant differences in white blood cell counts, neutrophils, lymphocytes, and C-reactive protein between adult-onset Still's disease group and sepsis group. However, patients in adult-onset Still's disease group showed higher ferritin and platelets and lower mean platelet volume and platelet distribution width than those in sepsis group (p<0.01 for both). Receiver operating characteristic curve analysis was performed to distinguish adult-onset Still's disease and sepsis. The area under the curve of mean platelet volume was 0.761 (95%CI 0.673-0.849), with a sensitivity of 79.1%, a specificity of 63.3%, and a cutoff value of 10.9 fL. In contrast, the area under the curve of combined ferritin and mean platelet volume was 0.90l (95%CI 0.837-0.965), with higher sensitivity (82.8%) and specificity (96.2%). Therefore, mean platelet volume could be used as a supplementary indicator to distinguish adult-onset Still's disease from sepsis.CONCLUSION:
We suggest that mean platelet volume could be used as a supplementary biomarker for differential diagnosis of adult-onset Still's disease and sepsis in addition to ferritin.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Still's Disease, Adult-Onset
/
Sepsis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Nanjing Gulou Yi Yuan: Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital/CN
/
Taixing Peoples Hospital/CN
/
The First Affiliated Hospital of Nanjing Medical University/CN
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