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Evaluation of factors affecting the frequency and clinical course of COVID-19 in patients using anti-TNF-alpha agents
Baslilar, Seyma; Pehlivan, Ozlem.
  • Baslilar, Seyma; Umraniye Training and Research Hospital. Department of Pulmonology. Istanbul. TR
  • Pehlivan, Ozlem; Umraniye Training and Research Hospital. Department of Rheumatology. Istanbul. TR
Rev. Assoc. Med. Bras. (1992) ; 67(9): 1286-1292, Sept. 2021. tab
Article in English | LILACS | ID: biblio-1351455
ABSTRACT
SUMMARY

OBJECTIVES:

Patients being treated with anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents were reported to have better prognosis related to COVID-19. We evaluated the factors affecting the frequency, clinical course, and outcome of COVID-19 in patients treated with anti-TNF-alpha agents.

METHODS:

Patients with rheumatoid diseases and chronic inflammatory bowel diseases treated with anti-TNF-alpha agents were evaluated retrospectively. The laboratory data in routine visits, frequency of COVID-19, pneumonia, hospitalization and/or intensive care unit (ICU) follow-up and, mortality were recorded. The factors related to COVID-19 frequency and clinical outcome were evaluated.

RESULTS:

A total of 324 patients (177 males [54.6%] and 147 females [45.4%], mean age 45.3±12.16 years) was included in the study. In all, 44 (13.6%) patients had COVID-19; of these, 11 (25%) developed pneumonia, 7 (15.9%) were hospitalized, and 1 (2.3%) was followed up in ICU. There was no mortality. The patients with COVID-19 pneumonia were older (mean age 52±11 years versus 41±12 years, p=0.01), had hypertension and coronary artery disease more frequently (5 cases [55.6%] versus 4 cases [44.4], p=0.02 and 2 cases [100%] versus 0 cases [0%], p=0.014, respectively), and lower eosinophil % (1.35±1.79% versus 2.3±1.45%, p=0.016). The diabetes mellitus was more frequent (66.7 versus 33.3%, p=0.013), and mean eosinophil % was lower among inpatients compared with outpatients (1.29±2.22% versus 2.19±1.37%, p=0.02).

CONCLUSIONS:

We concluded that the patients treated with anti-TNF-alpha agents having COVID-19 might have mild clinical course and better prognosis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tumor Necrosis Factor Inhibitors / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Umraniye Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Tumor Necrosis Factor Inhibitors / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Umraniye Training and Research Hospital/TR