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Fecal calprotectin levels used as a noninvasive method for screening for chronic gastritis in pediatric patients. A descriptive study
Demirbaş, Fatma; Çaltepe, Gönül; Abbasguliyev, Hasan; Kalaycı, Ayhan Gazi.
  • Demirbaş, Fatma; University Faculty of Medicine. Department of Pediatric Gastroenterology. Samsun. TR
  • Çaltepe, Gönül; University Faculty of Medicine. Department of Pediatric Gastroenterology. Samsun. TR
  • Abbasguliyev, Hasan; University Faculty of Medicine. Department of Pediatric Gastroenterology. Samsun. TR
  • Kalaycı, Ayhan Gazi; University Faculty of Medicine. Department of Pediatric Gastroenterology. Samsun. TR
São Paulo med. j ; 139(6): 564-569, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1352283
ABSTRACT
ABSTRACT

BACKGROUND:

Gastritis consists of inflammation of the gastric mucosa and is one of the main causes of dyspeptic symptoms in children.

OBJECTIVE:

To investigate the presence of inflammation by evaluating fecal calprotectin (FC) in children diagnosed with chronic gastritis. DESIGN AND

SETTING:

Descriptive study in Pediatric Gastroenterology Department of Ondokuz Mayis University Hospital in Turkey.

METHODS:

Between January 2016 and July 2018, FC levels were compared retrospectively in children with chronic gastritis (histopathology-based diagnosis), patients with inflammatory bowel disease (IBD) and healthy children.

RESULTS:

A total of 67 chronic gastritis patients (61.2% girls) with a mean age of 13.09 ± 3.5 years were evaluated. The mean FC levels were 153.4 μg/g in the chronic gastritis group, 589.7 μg/g in the IBD group and 43.8 μg/g in the healthy group. These levels were higher in chronic gastritis patients than in healthy individuals (P = 0.001) and higher in IBD patients than in the other two groups (P < 0.001). The FC level in the patients with chronic active gastritis (156.3 μg/g) was higher than in those with chronic inactive gastritis (150.95 μg/g) (P = 0.011). Among the patients with chronic active gastritis, the FC level was significantly higher in Helicobacter pylori-positive individuals than in negative individuals (P = 0.031).

CONCLUSION:

We confirmed the association between increased FC and chronic gastritis. Elevated FC levels may be seen in patients with chronic active gastritis. In order to be able to use FC as a screening tool for chronic gastritis, further studies in a larger study group are needed.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Inflammatory Bowel Diseases / Gastritis Type of study: Diagnostic study / Observational study / Risk factors / Screening study Limits: Adolescent / Child / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: University Faculty of Medicine/TR

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Full text: Available Index: LILACS (Americas) Main subject: Inflammatory Bowel Diseases / Gastritis Type of study: Diagnostic study / Observational study / Risk factors / Screening study Limits: Adolescent / Child / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: University Faculty of Medicine/TR