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Changes in serum albumin and liver enzymes following three different types of bariatric surgery: six-month follow-up. A retrospective cohort study
Zadeh, Mohadeseh Hassan; Zamaninour, Negar; Ansar, Hastimansooreh; Kabir, Ali; Pazouki, Abdolreza; Farsani, Gholamreza Mohammadi.
  • Zadeh, Mohadeseh Hassan; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Clinical Nutrition. Tehran. IR
  • Zamaninour, Negar; Iran University of Medical Sciences. Minimally Invasive Surgery Research Center. Tehran. IR
  • Ansar, Hastimansooreh; Iran University of Medical Sciences. Minimally Invasive Surgery Research Center. Tehran. IR
  • Kabir, Ali; Iran University of Medical Sciences. Minimally Invasive Surgery Research Center. Tehran. IR
  • Pazouki, Abdolreza; Iran University of Medical Sciences. Minimally Invasive Surgery Research Center. Tehran. IR
  • Farsani, Gholamreza Mohammadi; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Clinical Nutrition. Tehran. IR
São Paulo med. j ; 139(6): 598-606, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1352299
ABSTRACT
ABSTRACT

BACKGROUND:

Few reports have examined the effects of Roux-en-Y gastric bypass (RYGB), one-anastomosis gastric bypass (OAGB) and sleeve gastrectomy (SG) on changes to serum albumin (Alb) and liver enzyme levels.

OBJECTIVE:

To compare short-term post-surgery changes in serum Alb, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALKP) levels. Body composition changes were also measured and compared among three groups. DESIGN AND

SETTING:

Retrospective cohort study conducted in Tehran, Iran.

METHODS:

151 OAGB, RYGB and SG patients referred to the obesity clinic of Hazrat-e Rasool General Hospital, Tehran, Iran, were evaluated. Physical characteristics and biochemical parameters were measured pre-surgery and then after three and six months.

RESULTS:

Through repeated measurements to determine intragroup changes, significant changes in serum AST (P = 0.003) and ALT (P < 0.001) were observed in follow-ups. However, Alb levels did not change (P = 0.413). Body fat, fat-free mass and muscle mass decreased significantly in each group (P < 0.05). In a univariate general linear model for determining intergroup changes, SG showed greater decreases in ALT and AST at three and six months (P < 0.05) and in ALKP at six months (P = 0.037), compared with OAGB. There were no significant differences in Alb levels. Also, RYGB had a greater effect on reducing fat percentage (three months, P = 0.011; six months, P = 0.059) and fat mass (three months, P = 0.042) than OAGB.

CONCLUSION:

SG and RYGB may be superior to OAGB in reducing liver enzymes and body fat, respectively. However, Alb levels showed no significant differences.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Obesity, Morbid / Gastric Bypass / Bariatric Surgery Type of study: Etiology study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Iran Institution/Affiliation country: Iran University of Medical Sciences/IR / Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Obesity, Morbid / Gastric Bypass / Bariatric Surgery Type of study: Etiology study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Iran Institution/Affiliation country: Iran University of Medical Sciences/IR / Tehran University of Medical Sciences/IR