Decreased circulatory levels of Vitamin D in Vitiligo (ViViD Study): a meta-analysis
An. bras. dermatol
;
96(3): 284-294, May-June 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1355616
ABSTRACT
Abstract Background:
The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo.Methods:
Relevant studies were identified by searching PubMed and other databases. The random effects model was used to obtain standardized mean differences and pooled correlation coefficients. Meta-regression and sub-group analyses were conducted to explore heterogeneity. The presence of publication bias and the study robustness were tested using funnel plot and sensitivity analyses, respectively.Results:
This meta-analysis finally included 31 studies. Compared with controls, vitiligo patients showed significantly decreased serum Vitamin D levels (standardized mean difference = −1.03; p < 0.0001). The sub-group analysis showed that vitiligo patients with indoor/urban work had a significantly lower Vitamin D level when compared to their outdoor/rural counterparts (standardized mean differences = −0.45; p = 0.03). The sensitivity analysis indicated that no single study had a significant influence on the overall outcome, suggesting the robustness of this meta-analysis. Studylimitations:
Varied sample sizes and heterogeneous study populations from different countries are the limitations of this study. However, the between-study heterogeneity has been addressed by the random-effects model with meta-regression and sensitivity analyses.Conclusions:
This meta-analysis showed significantly decreased Vitamin D level in vitiligo, and its association with indoor/outdoor type of work of vitiligo patients. This study highlights the need to assess Vitamin D status for improving its level in vitiligo.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitamin D Deficiency
/
Vitiligo
Type of study:
Systematic reviews
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2021
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
All India Institute of Medical Sciences/IN
/
Telangana State Residential School & College/IN
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