Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line
Braz. arch. biol. technol
;
64: e21210069, 2021. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1355792
ABSTRACT
Abstract Rhus coriaria, popularly known as sumac, has been used as a spice powder in the Middle East for centuries. It contains a broad range of naturally occurring compounds such as flavonoids, proteins, anthocyanins and volatile oils. It showed a putative importance in treatment of different disorders including cancers. In the current study, R. coriaria fruit extract was used for green synthesis of silver nanostructures (Ag-NSs) and their anticancer activity was tested against human breast cancer cells (MCF-7). The aqueous fruit extract was prepared. The synthesis of Ag-NSs under different conditions was optimized. The optimal reaction medium comprised 12 concentration of fruit extract and 3 mM concentration of silver nitrate solution. The green-synthesized Ag-NSs were confirmed by using UV-Visible spectroscopy at a range 300-700 nm, transmission electron microscopy (TEM), X-ray diffraction (XRD) and zeta potential measurements. The anti-proliferative activity of Ag-NSs was confirmed with inhibitory activity on MCF-7 cell line growth. The results showed that the IC50 values at 24 and 48h were 14.27 and 13.4 μg/ml, respectively. In conclusion the results of this study provide a simple, rapid, non-toxic and eco-friendly protocol for green-synthesis of Ag-NSs, which could be used as an alternative and interesting approach for safe and simple synthesis of Ag nanoparticles for biomedical uses.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Practice guideline
Language:
English
Journal:
Braz. arch. biol. technol
Journal subject:
Biology
Year:
2021
Type:
Article
/
Project document
Affiliation country:
Iran
Institution/Affiliation country:
Alzahra University/IR
/
Zanjan University of Medical Sciences/IR
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