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Iraqi Propolis, Carbimazole, Levothyroxine and their Propolis Combinations Effects on Renal Histopathological Parameters in Female Rats
Al-Seray, Ghadeer Hamad; Abdullah, Asia Selman; AL‑Moziel, Muhsin Sagheer.
  • Al-Seray, Ghadeer Hamad; University of Basrah. College of Pharmacy. Department of Pharmacology and Toxicology. Basrah. IQ
  • Abdullah, Asia Selman; University of Basrah. College of Pharmacy. Department of Pharmacology and Toxicology. Basrah. IQ
  • AL‑Moziel, Muhsin Sagheer; University of Basrah. College of Pharmacy. Department of Pharmacology and Toxicology. Basrah. IQ
Braz. arch. biol. technol ; 64: e21210209, 2021. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1355811
ABSTRACT
Abstract Iraqi propolis (PR) have powerful antioxidants, free radical scavenger and anti-inflammatory constituents makes it to have a protective effect on renal function. The aim of this study is to evaluate the possible protective effect of Iraqi propolis (PR) on renal toxicity induced by Carbimazole (CB) and levothyroxine (TR) in rats. Forty-two adult female albino rats randomized into six groups control, PR, CB, TR, PR + CB and PR +TR. Rats orally treated by gavage for six weeks. Haematological and histopathological analyses performed. A significant increase in hemoglobin percentage, RBC count and Haematocrit percentage after exposure to PR + CB and PR + TR combinations compared to control. CB dose of 0.01mg /g for six weeks causes renal damage in female rats and TR dose of 0.1µg/g for six weeks causes renal degenerative effects. Rats treated with PR+TR show normal appearance in kidney tissue, glomeruli and renal tubules compared to thyroxin group alone. In addition, PR+ CB treatment show more improvement in renal tissue, normal glomeruli and renal tubules compared to CB alone. It is concluded that PR combination with CB or TR might have an effect on the blood, further studies needed to confirm this effect on human to be used for anemia accompanied thyroid disruptions. In addition, further studies needed to confirm renal protective effect on human to be used for this effect.


Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2021 Type: Article Affiliation country: Iraq Institution/Affiliation country: University of Basrah/IQ

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Full text: Available Index: LILACS (Americas) Type of study: Controlled clinical trial Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2021 Type: Article Affiliation country: Iraq Institution/Affiliation country: University of Basrah/IQ