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Association of vitamin D receptor gene polymorphisms with type 2 diabetes mellitus in Taif population: a case-control study / Associação de polimorfismos do gene do receptor de vitamina D com diabetes mellitus tipo 2 na população Taif: um estudo de caso-controle
Alkhedaide, A Q; Mergani, A; Aldhahrani, A A; Sabry, A; Soliman, M M; Nassan, M A; Ismail, T A.
  • Alkhedaide, A Q; Taif University, Turabah University College. Medical Laboratory Department. Turabah. SA
  • Mergani, A; Gezira University. National Cancer Institute. Department of Human Molecular Genetics. Gezira. SD
  • Aldhahrani, A A; Taif University, Turabah University College. Medical Laboratory Department. Turabah. SA
  • Sabry, A; Taif University. Faculty of Science. Department of Biology. Taif. SA
  • Soliman, M M; Taif University, Turabah University College. Medical Laboratory Department. Turabah. SA
  • Nassan, M A; Taif University, Turabah University College. Medical Laboratory Department. Turabah. SA
  • Ismail, T A; Taif University, Turabah University College. Medical Laboratory Department. Turabah. SA
Braz. j. biol ; 84: e250739, 2024. tab
Article in English | LILACS, VETINDEX | ID: biblio-1355896
ABSTRACT
Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the possible association of two identified mutations ApaI (rs7975232) and TaqI (rs731236). Eighty-nine healthy individuals and Fifty-six Type 2 Diabetic (T2D) patients were investigated using RFLP technique for genotyping and haplotyping as well. The distribution of Apal genotypes was not statistically significant among the control (P=0.65) as well as for diabetic patients (P=0.58). For Taql allele frequencies of T allele was 0.61 where of G allele was 0.39. The frequency distribution of Taql genotypes was not statistically significant among the control (P=0.26) as well as diabetic patients (P=0.17). Relative risk of the allele T of Apa1 gene is 1.28 and the odds ratio of the same allele is 1.53, while both estimates were < 1.0 of the allele G. Similarly, with the Taq1 gene the relative risk and the odds ratio values for the allele T are 1.09 and 1.27 respectively and both estimates of the allele C were 0.86 for the relative risk and 0.79 for the odds ratio. The pairwise linkage disequilibrium between the two SNPs Taq1/apa1 was statistically significant in control group (D = 0.218, D' = 0.925 and P value < 0.001) and similar data in diabetic groups (D = 0.2, D' = 0.875 and P value < 0.001). These data suggest that the T allele of both genes Apa1 and Taq1 is associated with the increased risk of type 2 diabetes. We think that we need a larger number of volunteers to reach a more accurate conclusion.
RESUMO
Resumo Várias razões podem estar subjacentes ao aumento dramático da diabetes mellitus tipo 2. Um desses motivos é a base genética e variações. Os polimorfismos do receptor da vitamina D estão associados a diferentes doenças, como artrite reumatoide e diabetes. O objetivo deste estudo é investigar a possível associação de duas mutações identificadas ApaI (rs7975232) e TaqI (rs731236). Oitenta e nove indivíduos saudáveis ​​e 56 pacientes com diabetes tipo 2 (T2D) foram investigados usando a técnica RFLP para genotipagem e haplotipagem também. A distribuição dos genótipos Apal não foi estatisticamente significativa entre o controle (P = 0,65), bem como para os pacientes diabéticos (P = 0,58). Para as frequências do alelo Taql, o alelo T foi de 0,61, onde o alelo G foi de 0,39. A distribuição de frequência dos genótipos Taql não foi estatisticamente significativa entre o controle (P = 0,26), bem como os pacientes diabéticos (P = 0,17). O risco relativo do alelo T do gene Apa1 é 1,28 e a razão de chances do mesmo alelo é 1,53, enquanto ambas as estimativas foram < 1,0 do alelo G. Da mesma forma, com o gene Taq1, os valores de risco relativo e razão de chances para o alelo T são 1,09 e 1,27, respectivamente, e ambas as estimativas do alelo C foram de 0,86 para o risco relativo e 0,79 para o odds ratio. O desequilíbrio de ligação par a par entre os dois SNPs Taq1 / apa1 foi estatisticamente significativo no grupo de controle (D = 0,218, D' = 0,925 e valor P < 0,001) e dados semelhantes em grupos diabéticos (D = 0,2, D' = 0,875 e valor P < 0,001). Esses dados sugerem que o alelo T de ambos os genes Apa1 e Taq1 está associado ao aumento do risco de diabetes tipo 2. Achamos que precisamos de um número maior de voluntários para chegar a uma conclusão mais precisa.

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Full text: Available Index: LILACS (Americas) Main subject: Receptors, Calcitriol / Diabetes Mellitus, Type 2 Type of study: Etiology study / Observational study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Braz. j. biol Year: 2024 Type: Article Institution/Affiliation country: Gezira University/SD / Taif University/SA / Taif University, Turabah University College/SA

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Full text: Available Index: LILACS (Americas) Main subject: Receptors, Calcitriol / Diabetes Mellitus, Type 2 Type of study: Etiology study / Observational study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Braz. j. biol Year: 2024 Type: Article Institution/Affiliation country: Gezira University/SD / Taif University/SA / Taif University, Turabah University College/SA