Impact of the 21-Gene Recurrence Score (Oncotype DX®) on adjuvant therapy decision-making: a collaborative multicenter cohort study from Argentina
Mastology (Online)
;
31: 1-7, 2021.
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1358952
ABSTRACT
Introduction:
At present, more than half of patients diagnosed with early-stage breast cancer (BC) and express hormonal receptors will receive some adjuvant chemotherapy scheme, but only a few of them would benefit in terms of survival. Genomic platforms allow a better understanding of the heterogeneity of different types of hormonal receptor-positive and HER2-negative BC. They have proven their validity as tools to identify those patients who will obtain a clear benefit with the indication of chemotherapy treatment. The aim of this study is to analyze the use of the genomic platform, namely, Oncotype Dx® and its impact on the indication of adjuvant treatment, evaluated mainly as the change in treatment indication.Methods:
Multicenter observational cohort study was performed in different Mastology units in Argentina. Patients underwent the Oncotype Dx to clarify the adjuvant treatment. Treatment decisions were settled before and after performing Oncotype Dx.Results:
From January 2013 to December 2018, 211 patients with luminal A or B and HER2-negative breast carcinomas, who underwent the Oncotype Dx, were included. Based on our records, 40% of the patients change the indication of adjuvant treatment after the performance of the Oncotype Dx. Of these, 24% of patients who underwent initial endocrine therapy only adjusted their treatment with the addition of chemotherapy. Among patients with an initial CTH recommendation, 49% were able to receive endocrine therapy only when, due to traditional prognostic factors, they would have received chemotherapy.Conclusions:
In our population, the use of the Recurrence Score was clinically significant in relation to the change of the established treatments. Consequently, it is a very important tool and a decisive factor in the adjuvant indication in patients with positive hormonal receptors and HER2neu-negative early BC.
Full text:
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Index:
LILACS (Americas)
Type of study:
Controlled clinical trial
/
Etiology study
/
Practice guideline
/
Observational study
/
Prognostic study
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
Mastology (Online)
Journal subject:
Neoplasias da Mama
Year:
2021
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno" Ciudad Autónoma de Buenos Aires (Buenos Aires), Argentina/AR
/
Centro de Mastología de Rosario Rosario (Santa Fe), Argentina/AR
/
Hospital Británico Ciudad Autónoma de Buenos Aires (Buenos Aires), Argentina/AR
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Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires (Buenos Aires), Argentina/AR
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Hospital Italiano de La Plata La Plata (Buenos Aires), Argentina/AR
/
Hospital Universitario Austral Pilar (Buenos Aires), Argentina/AR
/
Instituto Alexander Fleming Ciudad Autónoma de Buenos Aires (Buenos Aires), Argentina/AR
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