Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital
An. bras. dermatol
;
97(1): 14-21, Jan.-Feb. 2022. tab
Article
in English
| LILACS
| ID: biblio-1360096
ABSTRACT
Abstract Background:
Mucocutaneous adverse events are common during anticancer treatment, with variable consequences for the patient and their therapeutic regimen.Objective:
To evaluate the most common adverse events, as well as the drugs associated with their appearance and the consequences for cancer treatment.Methods:
A retrospective study was carried out through the analysis of patients treated at the Clinical Dermatology Unit of a public oncologic hospital.Results:
A total of 138 patients with 200 adverse events were evaluated. The most commonly identified adverse events were nail and periungual changes (20%), papulopustular eruptions (13%), acneiform eruptions (12%), hand-foot syndrome (6.5%), hand-foot skin reaction (6%), and xerosis (6%). The most frequently associated antineoplastic treatment groups were classical chemotherapy (46.2%), target therapy (32.3%), and other non-antineoplastic drugs used in neoplasia protocols (16.5%). Of the total number of patients, 17.4% had their treatment suspended or changed due to a dermatological adverse event. Studylimitations:
Retrospective study and analysis of patients who were referred for specialized dermatological examination only, not allowing the assessment of the actual incidence of adverse events.Conclusion:
A wide variety of dermatological manifestations are secondary to antineoplastic treatment with several different drugs resulting, not rarely, in the interruption or modification of therapeutic regimens.
Full text:
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Index:
LILACS (Americas)
Main subject:
Neoplasms
/
Antineoplastic Agents
Type of study:
Practice guideline
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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