Your browser doesn't support javascript.
loading
Solubility enhancementofcefixime trihydrate by solid dispersions using hydrotropic solubilization technique and their characterization
Agrawal, Gopal Prasad; Maheshwari, Rajesh Kumar; Mishra, Pradeep.
  • Agrawal, Gopal Prasad; GLA University. Institute of Pharmaceutical Research. Mathura. IN
  • Maheshwari, Rajesh Kumar; Shri G. S. Institute of Technology and Science. Department of Pharmacy. Indore. IN
  • Mishra, Pradeep; GLA University. Institute of Pharmaceutical Research. Mathura. IN
Braz. J. Pharm. Sci. (Online) ; 58: e18553, 2022. tab, graf
Article in English | LILACS | ID: biblio-1360166
ABSTRACT
Abstract The aqueous solubility of cefixime trihydrate (a water insoluble drug) using different hydrotropic agents was determined and solid dispersions of cefixime trihydrate were prepared by hydrotropic solubilization technique. The drugs content were determined. The aqueous solubility of v was increased many fold in presence of sodium acetate trihydrate as hydrotropic agent. This hydrotropic agent was used to prepare solid dispersion of cefixime trihydrate. Cefixime trihydrate and sodium acetate trihydrate were accurately weighed and taken in a 200 mL beaker. Distilled water 10-15 mL was taken to dissolve hydrotropic agent using heat (48-50 °C). The drug was then added to it and magnetically stirred till whole mass get viscous. The solid dispersions of cefixime trihydrate were characterized by XRD, DSC and IR studies. DSC thermogram, XRD and Infra-Red spectra were studied. Solid dispersions, thus prepared, showed faster release of the drug as compared to pure drug and physical mixture.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Solubility / Pharmaceutical Preparations / Methods Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: India Institution/Affiliation country: GLA University/IN / Shri G. S. Institute of Technology and Science/IN

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Solubility / Pharmaceutical Preparations / Methods Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: India Institution/Affiliation country: GLA University/IN / Shri G. S. Institute of Technology and Science/IN