Solubility enhancementofcefixime trihydrate by solid dispersions using hydrotropic solubilization technique and their characterization
Braz. J. Pharm. Sci. (Online)
;
58: e18553, 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1360166
ABSTRACT
Abstract The aqueous solubility of cefixime trihydrate (a water insoluble drug) using different hydrotropic agents was determined and solid dispersions of cefixime trihydrate were prepared by hydrotropic solubilization technique. The drugs content were determined. The aqueous solubility of v was increased many fold in presence of sodium acetate trihydrate as hydrotropic agent. This hydrotropic agent was used to prepare solid dispersion of cefixime trihydrate. Cefixime trihydrate and sodium acetate trihydrate were accurately weighed and taken in a 200 mL beaker. Distilled water 10-15 mL was taken to dissolve hydrotropic agent using heat (48-50 °C). The drug was then added to it and magnetically stirred till whole mass get viscous. The solid dispersions of cefixime trihydrate were characterized by XRD, DSC and IR studies. DSC thermogram, XRD and Infra-Red spectra were studied. Solid dispersions, thus prepared, showed faster release of the drug as compared to pure drug and physical mixture.
Full text:
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Index:
LILACS (Americas)
Main subject:
Solubility
/
Pharmaceutical Preparations
/
Methods
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
GLA University/IN
/
Shri G. S. Institute of Technology and Science/IN
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