AMPA and angiotensin type 1 receptors are necessary for hemorrhage-induced vasopressin secretion
Braz. j. med. biol. res
;
55: e11635, 2022. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1360232
ABSTRACT
Hypovolemia induced by hemorrhage is a common clinical complication, which stimulates vasopressin (AVP) secretion by the neurohypophysis in order to retain body water and maintain blood pressure. To evaluate the role of brain L-glutamate and angiotensin II on AVP secretion induced by hypovolemia we induced hemorrhage (∼25% of blood volume) after intracerebroventricular (icv) administration of AP5, NBQX, or losartan, which are NMDA, AMPA, and AT1 receptor antagonists, respectively. Hemorrhage significantly increased plasma AVP levels in all groups. The icv injection of AP5 did not change AVP secretion in response to hemorrhage. Conversely, icv administration of both NBQX and losartan significantly decreased plasma AVP levels after hemorrhage. Therefore, the blockade of AMPA and AT1 receptors impaired AVP secretion in response to hemorrhage, suggesting that L-glutamate and angiotensin II acted in these receptors to increase AVP secretion in response to hemorrhage-induced hypovolemia.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2022
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Escola Paulista de Medicina Universidade Federal de São Paulo/BR
/
Universidade Federal Rural do Rio de Janeiro/BR
/
Universidade de São Paulo/BR
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