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Vitamin A deficiency and association between serum retinol and IGF-1 concentrations in Brazilian children with Down syndrome
Ferraz, Ivan Savioli; Vieira, Débora Mônica Costa; Ciampo Jr, Luiz Antonio Del; Ued, Fábio da Veiga; Almeida, Ane Cristina Fayão; Jordão Jr, Alceu Afonso; Aragon, Davi Casale; Martinez, Edson Zangiacomi; Martinelli Jr, Carlos Eduardo; Nogueira-de-Almeida, Carlos Alberto.
  • Ferraz, Ivan Savioli; Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto. BR
  • Vieira, Débora Mônica Costa; Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto. BR
  • Ciampo Jr, Luiz Antonio Del; Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto. BR
  • Ued, Fábio da Veiga; Universidade de São Paulo. Departamento de Ciências da Saúde. Ribeirão Preto. BR
  • Almeida, Ane Cristina Fayão; Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto. BR
  • Jordão Jr, Alceu Afonso; Universidade de São Paulo. Departamento de Ciências da Saúde. Ribeirão Preto. BR
  • Aragon, Davi Casale; Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto. BR
  • Martinez, Edson Zangiacomi; Universidade de São Paulo. Departamento de Medicina Social. Ribeirão Preto. BR
  • Martinelli Jr, Carlos Eduardo; Universidade de São Paulo. Departamento de Pediatria. Ribeirão Preto. BR
  • Nogueira-de-Almeida, Carlos Alberto; Universidade Federal de São Carlos. Departamento de Medicina. São Carlos. BR
J. pediatr. (Rio J.) ; 98(1): 76-83, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360550
ABSTRACT
Abstract

Objective:

To determine the prevalence of vitamin A deficiency (VAD) and serum concentrations of retinol, correlating them with IGF-1 concentrations in preschoolers with DS.

Methods:

Cross-sectional study was conducted on 47 children with DS aged 24 to 72 months, in Ribeirão Preto, Brazil. VAD was determined by the relative dose-response (RDR) test. Retinol serum concentration ≤ 0.70 μmol/L and IGF-1 serum concentration below the 3rd percentile for sex and age were considered to represent deficiency. C-reactive protein (CRP) was determined at the beginning of the study. Weight, height, and information about fever and/or diarrhea were obtained at the beginning of the study.

Results:

VAD prevalence was 25.5% (12/47), and 74.5% (35/47) of the children had deficient retinol before the intervention. CRP was not associated with VAD. Mean IGF-1 were 103.5 ng/mL (SD = 913) for the group with VAD and 116.3 ng/mL (SD = 54.9) for the group with no VAD (p-value = 0.85); 8.5% (4/47) of the children showed deficient IGF-1, but without VAD. No association was observed between VAD and IGF-1 deficiency. A moderate positive correlation was observed between pre-intervention retinol and IGF-1 (ρ = 0.37; p-value = 0.01).

Conclusion:

a high prevalence of VAD and deficient retinol was observed and there was a positive correlation between serum retinol and IGF-1.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Vitamin A Deficiency / Insulin-Like Growth Factor I / Down Syndrome Type of study: Observational study / Prevalence study / Risk factors Limits: Child / Child, preschool / Humans Country/Region as subject: South America / Brazil Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Carlos/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Vitamin A Deficiency / Insulin-Like Growth Factor I / Down Syndrome Type of study: Observational study / Prevalence study / Risk factors Limits: Child / Child, preschool / Humans Country/Region as subject: South America / Brazil Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Carlos/BR / Universidade de São Paulo/BR