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Overweight/obesity in adolescents with phenylketonuria: protective and predisposing factors
Silveira, Adriana Márcia; Lima, Poliane Lopes; Alves, Michelle Rosa Andrade; Soares, Rosângelis Del Lama; Kanufre, Viviane de Cássia; Rodrigues, Valéria de Melo; Starling, Ana Lúcia Pimenta; Norton, Rocksane de Carvalho; Aguiar, Marcos José Burle de.
  • Silveira, Adriana Márcia; Universidade Federal de Minas Gerais (UFMG). Departamento de Pediatria. Belo Horizonte. BR
  • Lima, Poliane Lopes; Faculdade de Minas. Departamento de Nutrição. Belo Horizonte. BR
  • Alves, Michelle Rosa Andrade; Pontifícia Universidade Católica de Minas Gerais (PUC-Minas). Departamento de Nutrição. Belo Horizonte. BR
  • Soares, Rosângelis Del Lama; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Kanufre, Viviane de Cássia; Universidade Federal de Minas Gerais (UFMG). Belo Horizonte. BR
  • Rodrigues, Valéria de Melo; Universidade Federal de Minas Gerais (UFMG). Departamento de Pediatria. Belo Horizonte. BR
  • Starling, Ana Lúcia Pimenta; Universidade Federal de Minas Gerais (UFMG). Departamento de Pediatria. Belo Horizonte. BR
  • Norton, Rocksane de Carvalho; Universidade Federal de Minas Gerais (UFMG). Departamento de Pediatria. Belo Horizonte. BR
  • Aguiar, Marcos José Burle de; Universidade Federal de Minas Gerais (UFMG). Departamento de Pediatria. Belo Horizonte. BR
J. pediatr. (Rio J.) ; 98(1): 104-110, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360562
ABSTRACT
Abstract

Objective:

To estimate the prevalence and factors associated with overweight/obesity development in adolescents with early diagnosed phenylketonuria treated exclusively by diet.

Methodology:

In this cross-sectional study anthropometric measurements, serum phenylalanine levels, and 10 metabolites associated with lipid and carbohydrate metabolism were analyzed in 101 adolescents aged 10-20 years. Adolescents were categorized into overweight/obesity and eutrophic/low body mass index groups. These patients were compared using Student's t-test, Pearson's chi-square test, Wald's chi-square test for multivariate analysis. Further, to verify whether the prevalence of overweight/obesity found in the study population was similar to that in the general population, the authors compared the nutritional status of 46 patients aged 13-17 years with that of healthy students of the same age from the National School Health Survey using the chi-square test for adherence. The significance threshold was p < 0.5.

Results:

The prevalence of overweight/obesity in adolescents was 27.7%. There was no difference in prevalence between sexes. Older age was a protective factor and Increased Homeostasis Model Assessment Insulin Resistance index and high phenylalanine and low-density lipoprotein cholesterol levels were predictive factors for overweight/obesity. The equality hypothesis was not rejected in the comparison of nutritional states of 46 patients aged 13-17 years and healthy students of the same age.

Conclusion:

The prevalence of overweight/obesity in phenylketonuria adolescents was similar to what is found in healthy adolescents.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Phenylketonurias / Pediatric Obesity Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Humans Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Minas/BR / Pontifícia Universidade Católica de Minas Gerais (PUC-Minas)/BR / Universidade Federal de Minas Gerais (UFMG)/BR

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Full text: Available Index: LILACS (Americas) Main subject: Phenylketonurias / Pediatric Obesity Type of study: Diagnostic study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Humans Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Minas/BR / Pontifícia Universidade Católica de Minas Gerais (PUC-Minas)/BR / Universidade Federal de Minas Gerais (UFMG)/BR