Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease
Mem. Inst. Oswaldo Cruz
;
117: e210395, 2022.
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1360602
ABSTRACT
Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Important observations have been made, such as (i) the ability of Trypanosoma cruzi in activating latent TGF-β; (ii) the potential involvement of TGF-β pathway on T. cruzi invasion of host cells; (iii) association of TGF-β with parasite intracellular replication; (iv) cardiac fibrosis development and maintenance; (v) disruption of Connexin-43 plaque structures and (vi) inflammation and immune response. In this perspective article we intend to discuss the advances of the potential use of new therapies targeting TGF-β to treat the cardiac alterations of Chagas disease-affected patients.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2022
Type:
Article
Affiliation country:
Brazil
/
France
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Institut National de la Santé et de la Recherche Médicale/FR
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