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Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease
Waghabi, Mariana Caldas; Ferreira, Roberto Rodrigues; Abreu, Rayane da Silva; Degrave, Wim; de Souza, Elen Mello; Bailly, Sabine; Feige, Jean-Jacques; de Araújo-Jorge, Tania C.
  • Waghabi, Mariana Caldas; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro. BR
  • Ferreira, Roberto Rodrigues; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro. BR
  • Abreu, Rayane da Silva; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro. BR
  • Degrave, Wim; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro. BR
  • de Souza, Elen Mello; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro. BR
  • Bailly, Sabine; Institut National de la Santé et de la Recherche Médicale. Biology of Cancer and Infection Laboratory. Grenoble. FR
  • Feige, Jean-Jacques; Institut National de la Santé et de la Recherche Médicale. Biology of Cancer and Infection Laboratory. Grenoble. FR
  • de Araújo-Jorge, Tania C; Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 117: e210395, 2022.
Article in English | LILACS-Express | LILACS | ID: biblio-1360602
ABSTRACT
Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Important observations have been made, such as (i) the ability of Trypanosoma cruzi in activating latent TGF-β; (ii) the potential involvement of TGF-β pathway on T. cruzi invasion of host cells; (iii) association of TGF-β with parasite intracellular replication; (iv) cardiac fibrosis development and maintenance; (v) disruption of Connexin-43 plaque structures and (vi) inflammation and immune response. In this perspective article we intend to discuss the advances of the potential use of new therapies targeting TGF-β to treat the cardiac alterations of Chagas disease-affected patients.


Full text: Available Index: LILACS (Americas) Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2022 Type: Article Affiliation country: Brazil / France Institution/Affiliation country: Fundação Oswaldo Cruz-Fiocruz/BR / Institut National de la Santé et de la Recherche Médicale/FR

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Full text: Available Index: LILACS (Americas) Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2022 Type: Article Affiliation country: Brazil / France Institution/Affiliation country: Fundação Oswaldo Cruz-Fiocruz/BR / Institut National de la Santé et de la Recherche Médicale/FR