Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease
Rev. Inst. Med. Trop. São Paulo (Online)
;
64: e4, 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1360790
ABSTRACT
ABSTRACT The present study aimed to establish a population pharmacokinetic (PopPK) modeling of benznidazole (BZD) in Brazilian patients with chronic Chagas disease. This was part of a Brazilian prospective cohort study with eight patients diagnosed with Chagas disease during the beginning of BZD treatment up to the 60th day. On the 15th day of treatment, a blood sampling was collected and analyzed. A one-compartment PK model was developed using Pmetrics. Patients with an average age of 50.3 (SD 6.2) years old, 6 female patients and 2 males, 70.2 kg (14.2), receiving a 5 mg/Kg/day dose were included. PK parameters estimated for CL, V and Ka were 6.27 L/h, 38.97 L and 1.66 h-1, respectively. This is the first study to establish a population pharmacokinetic modeling of BZD in Brazilian patients with chronic Chagas disease. Therefore, further studies are needed to obtain the complete characterization of BZD pharmacokinetics.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Inst. Med. Trop. São Paulo (Online)
Journal subject:
Medicina Tropical
Year:
2022
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Infectologia Emilio Ribas/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade Federal de São João del-Rei/BR
/
Universidade de São Paulo/BR
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