Overview of polymyxin resistance in Enterobacteriaceae
Rev. Soc. Bras. Med. Trop
; 55: e0349, 2022. graf
Article
in En
|
LILACS-Express
| LILACS
| ID: biblio-1360814
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
Full text:
1
Index:
LILACS
Type of study:
Risk_factors_studies
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2022
Type:
Article
/
Project document