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Overview of polymyxin resistance in Enterobacteriaceae
Silva, Kesia Esther da; Rossato, Luana; Leite, Andressa Ferraz; Simionatto, Simone.
Affiliation
  • Silva, Kesia Esther da; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Rossato, Luana; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Leite, Andressa Ferraz; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
  • Simionatto, Simone; Universidade Federal da Grande Dourados. Laboratório de Pesquisa em Ciências da Saúde. Dourados. BR
Rev. Soc. Bras. Med. Trop ; 55: e0349, 2022. graf
Article in En | LILACS-Express | LILACS | ID: biblio-1360814
Responsible library: BR1.1
ABSTRACT
ABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
Key words

Full text: 1 Index: LILACS Type of study: Risk_factors_studies Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2022 Type: Article / Project document

Full text: 1 Index: LILACS Type of study: Risk_factors_studies Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2022 Type: Article / Project document