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Extending the Indications of 5-Aminolevulinic Acid for Fluorescence-Guided Surgery for Different Central Nervous System Tumors: A Series of 255 Cases in Latin America
Silva Jr, Erasmo Barros da; Ramina, Ricardo; Coelho Neto, Maurício; Machado, Guilherme Augusto de Souza; Cavalcanti, Marcella Santos; Silva, Joseph Franklin Chenisz da.
  • Silva Jr, Erasmo Barros da; Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba. Curitiba. BR
  • Ramina, Ricardo; Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba. Curitiba. BR
  • Coelho Neto, Maurício; Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba. Curitiba. BR
  • Machado, Guilherme Augusto de Souza; Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba. Curitiba. BR
  • Cavalcanti, Marcella Santos; Departament of Neuropathology, Instituto de Neurologia de Curitiba. Curitiba. BR
  • Silva, Joseph Franklin Chenisz da; Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba. Curitiba. BR
Arq. bras. neurocir ; 41(1): 35-42, 07/03/2022.
Article in English | LILACS | ID: biblio-1362074
ABSTRACT
Introduction Fluorescence guidance with 5-aminolevulinic acid (5-ALA) is a safe and reliable tool in total gross resection of intracranial tumors, especially malignant gliomas and cases of metastasis. In the present retrospective study, we have analyzed 5-ALA-induced fluorescence findings in different central nervous system (CNS) lesions to expand the indications of its use in differential diagnoses. Objectives To describe the indications and results of 5-ALA fluorescence in a series of 255 cases. Methods In 255 consecutive cases, we recorded age, gender, intraoperative 5-ALA fluorescence tumor response, and 5-ALA postresection status, as well the complications related to the method. Postresection was classified as '5-ALA free' or '5-ALA residual'. The diagnosis of histopathological tumor was established according to the current classification of the World Health Organization (WHO). Results There were 195 (76.4%) 5-ALA positive cases, 124 (63.5%) of whom underwent the '5-ALA free' resection. The findings in the positive cases were 135 gliomas of all grades; 19 meningiomas; 4 hemangioblastomas; 1 solitary fibrous tumor; 27 metastases; 2 diffuse large B cell lymphomas; 2 cases of radionecrosis; 1 inflammatory disease; 2 cases of gliosis; 1 cysticercosis; and 1 immunoglobulin G4-related disease.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Brain Neoplasms / Surgery, Computer-Assisted / Aminolevulinic Acid / Microscopy, Fluorescence Type of study: Practice guideline / Observational study / Risk factors Language: English Journal: Arq. bras. neurocir Journal subject: Cirurgia / Neurosurgery Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Departament of Neuropathology, Instituto de Neurologia de Curitiba/BR / Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba/BR

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Full text: Available Index: LILACS (Americas) Main subject: Brain Neoplasms / Surgery, Computer-Assisted / Aminolevulinic Acid / Microscopy, Fluorescence Type of study: Practice guideline / Observational study / Risk factors Language: English Journal: Arq. bras. neurocir Journal subject: Cirurgia / Neurosurgery Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Departament of Neuropathology, Instituto de Neurologia de Curitiba/BR / Department of Neurosurgery, Section of Neuro-oncology, Instituto de Neurologia de Curitiba/BR