Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature
Arq. bras. neurocir
;
38(3): 183-198, 15/09/2019.
Article
in English
| LILACS
| ID: biblio-1362590
ABSTRACT
Depression is the leading cause of disability worldwide, and it is related to high suicide rates. Furthermore, a great number of patients do not respond to any of the available treatments. Deep brain stimulation (DBS), a versatile technology with expanding indications, is considered a potential treatment for resistant depression. However, in over 10 years of clinical research, its efficacy has not been completely proven. Although new trials using DBS for treatment-resistant depression keep emerging, two of the three Level I evidence-based studies recently conducted have not provided conclusive data. Methodological limitations andmajor biases have compromised the obtention of clearer results. In this systematic review of the literature, we intend to critically assess the clinical trials performed in this field.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Deep Brain Stimulation
/
Depressive Disorder, Treatment-Resistant
Type of study:
Systematic reviews
Language:
English
Journal:
Arq. bras. neurocir
Journal subject:
Cirurgia
/
Neurosurgery
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Pontifícia Universidade Católica de Goiás/BR
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