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Radioterapia y 5-fluorouracilo-cisplatino en el tratamiento del cáncer de cuello uterino de alto riesgo / Radiotherapy and 5-fluorouracil-cisplatin treatment for high-risk uterine cervical cancer
Reyna Villasmil , Eduardo; Mejía Montilla, Yorly; Torres Cepeda , Duly; Reyna Villasmil , Nadia; Fernández, Andreina.
  • Reyna Villasmil , Eduardo; Hospital Central Dr. Urquinaona. Servicio de Obstetricia y Ginecología. Maracaibo. VE
  • Mejía Montilla, Yorly; La Universidad del Zulia. Maracaibo. VE
  • Torres Cepeda , Duly; Hospital Central Dr. Urquinaona. Servicio de Obstetricia y Ginecología. Maracaibo. VE
  • Reyna Villasmil , Nadia; La Universidad del Zulia. Maracaibo. VE
  • Fernández, Andreina; La Universidad del Zulia. Facultad de Medicina. Maracaibo. VE
Repert.Med.Cir ; 30(3): 248-255, 2021. ilus., tab.
Article in English, Spanish | LILACS, COLNAL | ID: biblio-1363530
RESUMEN

Objetivo:

evaluar la eficacia de la combinación de radioterapia y 5-fluorouracilo-cisplatino en el tratamiento del cáncer de cuello uterino de alto riesgo. Materiales y

métodos:

estudio retrospectivo en el que se revisaron los datos de pacientes tratadas en el periodo enero 2009 a diciembre 2019 en el Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela. Se revisaron los registros clínicos de todas las pacientes sometidas a histerectomía radical y linfadenectomía pélvica bilateral que recibieron quimio-radioterapia concurrente adyuvante con 5-fluorouracilo-cisplatino (grupo de tratamiento) y se compararon con quienes no fueron manejadas con este régimen, las que no recibieron ningún tratamiento adyuvante o solo fueron tratadas con radioterapia (grupo control). Se evaluaron las características generales, efectos adversos del tratamiento, recurrencias de la enfermedad y supervivencia.

Resultados:

para el análisis final quedaron 164 pacientes, de las cuales 115 (70,1%) fueron del grupo de tratamiento y 49 (29,9%) del control. No se encontraron diferencias estadísticamente significativas en las características clínicas entre ambos grupos (p = ns); sí las hubo en la frecuencia de recurrencias a distancia (p = 0,0056). La supervivencia libre de progresión y la global de ambos grupos no mostraron diferencias significativas (p = 0,2678 y p = 0,3452).

Conclusión:

no existen beneficios evidentes del uso de 5-fluorouracilo-cisplatino desde el punto de vista de progresión o supervivencia general, en pacientes con carcinoma cuello uterino de alto riesgo.
ABSTRACT

Objective:

to evaluate the efficacy of radiotherapy combined with 5-fluorouracil-cisplatin in the treatment of high-risk uterine cervical cancer. Materials and

methods:

Retrospective study, in which the data of patients treated between January 2009 and December 2019 at Hospital Central "Dr. Urquinaona", Maracaibo, Venezuela, was analyzed. The clinical records of all patients who underwent radical hysterectomy and bilateral pelvic lymphadenectomy and received adjuvant concurrent chemoradiotherapy with 5-fluorouracil-cisplatin (treatment group) compared with those patients not managed with this regimen, those who did not receive any adjuvant treatment or received only radiotherapy (control group), were reviewed. The general characteristics, treatment adverse effects, disease recurrences and survival rate were evaluated.

Results:

164 patients remained for the final analysis, of which 115 (70.1%) were in the treatment group and 49 (29.9%) in the control group. No statistically significant differences were found in the clinical characteristics of patients between the two groups (p = ns); while differences in the distant recurrence rate (p = 0.0056) were found. Progression-free survival and overall survival in both groups did not show significant differences (p = 0.2678 and p = 0.3452).

Conclusion:

there is no evident benefit of the use of 5-fluorouracil-cisplatin in terms of progression or overall survival in patients with high-risk cervical carcinoma.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Radiotherapy / Uterine Cervical Neoplasms / Fluorouracil Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans Language: English / Spanish Journal: Repert.Med.Cir Year: 2021 Type: Article Affiliation country: Venezuela Institution/Affiliation country: Hospital Central Dr. Urquinaona/VE / La Universidad del Zulia/VE

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Full text: Available Index: LILACS (Americas) Main subject: Radiotherapy / Uterine Cervical Neoplasms / Fluorouracil Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans Language: English / Spanish Journal: Repert.Med.Cir Year: 2021 Type: Article Affiliation country: Venezuela Institution/Affiliation country: Hospital Central Dr. Urquinaona/VE / La Universidad del Zulia/VE