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Fibroblast growth factor receptor 3 gene (FGFR3) mutations in high-grade muscle-invasive urothelial bladder cancer in a Brazilian population: evaluation and prevalence
Monteiro, Camila Ribeiro de Arruda; Korkes, Fernando; Krutman-Zveibil, Deborah; Glina, Sidney.
  • Monteiro, Camila Ribeiro de Arruda; Centro Universitário FMABC. Santo André. BR
  • Korkes, Fernando; Centro Universitário FMABC. Santo André. BR
  • Krutman-Zveibil, Deborah; Centro Universitário FMABC. Santo André. BR
  • Glina, Sidney; Centro Universitário FMABC. Santo André. BR
Einstein (Säo Paulo) ; 20: eAO6450, 2022. tab, graf
Article in English | LILACS | ID: biblio-1364794
Responsible library: BR1.1
ABSTRACT
ABSTRACT Objective To understand the feasibility of FGFR3 tests in the Brazilian public health context, and to sample the mutational burden of this receptor in high-grade muscle invasive bladder cancer. Methods A total of 31 patients with high-grade muscle-invasive bladder cancer were included in the present study. Either transurethral resection of bladder tumor or radical cystectomy specimens were analyzed. Formalin-fixed paraffin-embedded tissue blocks were sectioned, hematoxylin and eosin stained, and histologic sections were reviewed. Total RNA was extracted using the RNeasy DSP formalin-fixed paraffin-embedded kit. Qualitative results were displayed in Rotor-Gene AssayManager software. Results Six patients were excluded. From the samples analyzed, four (16.7%) were considered inadequate and could not have their RNA extracted. Two patients presented FGFR3 mutations, accounting for 9.5% of material available for adequate analysis. The two mutations detected included a Y373C mutation in a male patient and a S249C mutation in a female patient. Conclusion FGFR3 mutations could be analyzed in 84% of our cohort and occurred in 9.5% of patients with high-grade muscle invasive bladder cancer in this Brazilian population. FGFR3 gene mutations are targets for therapeutic drugs in muscle-invasive bladder cancer. For this reason, know the frequency of these mutations can have a significant impact on public health policies and costs provisioning.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Receptor, Fibroblast Growth Factor, Type 3 Type of study: Prevalence study / Qualitative research / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Universitário FMABC/BR

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Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Receptor, Fibroblast Growth Factor, Type 3 Type of study: Prevalence study / Qualitative research / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Universitário FMABC/BR