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Lipoprotein apheresis efficacy and challenges: single center experience
Özdemir, Zehra Narlı; Şahin, Uğur; Yıldırım, Yasin; Kaya, Cansın Tulunay; İlhan, Osman.
  • Özdemir, Zehra Narlı; Ankara City Hospital. Ankara. TR
  • Şahin, Uğur; Medicana International Ankara Hospital. Ankara. TR
  • Yıldırım, Yasin; Ankara University School of Medicine. Ankara. TR
  • Kaya, Cansın Tulunay; Ankara University School of Medicine. Ankara. TR
  • İlhan, Osman; Ankara University School of Medicine. Ankara. TR
Hematol., Transfus. Cell Ther. (Impr.) ; 44(1): 56-62, Jan.-Mar. 2022. tab, graf
Article in English | LILACS | ID: biblio-1364891
ABSTRACT
Abstract Introduction Lipoprotein apheresis (LA) is an extracorporeal therapy which removes apolipoprotein B-containing particles from the circulation. We evaluated techniques and efficiency of lipoprotein apheresis procedures applied to patients with familial and non-familial hypercholesterolemia (FH) at our center. Methods We retrospectively evaluated 250 LA procedures applied to 27 patients with dyslipidemia between March 2011 and August 2019. Results A total of 27 patients, of whom 19 (70.4%) were male and 8 (29.6%), female, were included. Eighteen (66.7%), 6 (22.2%) and 3 (11.1%) patients were diagnosed with non-FH, homozygous FH (HoFH) and heterozygous FH (HeFH), respectively. Two different apheresis techniques, direct adsorption of lipoproteins (DALI) (48.8%) and double filtration plasmapheresis (DFPP) (51.2%), were used. The change in the serum total cholesterol (TC) level was the median 302 mg/dl (171-604 mg/dl) (60.4%) in HoFH patients, 305 mg/dl (194-393 mg/dl) (60.8%) in HeFH patients and 227 mg/dl (75-749 mg/dl) (65.3%) in non-FH patients. The change in the serum low-density lipoprotein (LDL) level was the median 275 mg/dl (109-519 mg/dl) (64.2%), 232 mg/dl (207-291 mg/dl) (64.5%) and 325 mg/dl (22-735 mg/dl) (70.9%) in patients with HoFH, HeFH and non-FH, respectively. A significantly effective reduction in serum lipid levels, including TC, LDL and triglycerides, was achieved in all patients, regardless of the technique, p< .001. The decrease in the serum TC and LDL levels was significantly higher in the DFPP, compared to the DALI, being 220 mg/dl (-300 to 771) vs 184 mg/dl (64-415), p< .001 and 196 mg/dl (11-712) vs 157 mg/dl (54-340), p< .001, respectively. Conclusions Our results showed that LA is a highly effective treatment in reducing serum lipid levels and safe, without any major adverse event.
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Full text: Available Index: LILACS (Americas) Main subject: Blood Component Removal / Lipoproteins Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male Language: English Journal: Hematol., Transfus. Cell Ther. (Impr.) Journal subject: Hematologia / TransfusÆo de Sangue Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara City Hospital/TR / Ankara University School of Medicine/TR / Medicana International Ankara Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Blood Component Removal / Lipoproteins Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male Language: English Journal: Hematol., Transfus. Cell Ther. (Impr.) Journal subject: Hematologia / TransfusÆo de Sangue Year: 2022 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara City Hospital/TR / Ankara University School of Medicine/TR / Medicana International Ankara Hospital/TR