Assessment of serum endocan levels in patients with beta-thalassemia minor
Rev. Assoc. Med. Bras. (1992)
;
68(2): 147-151, Feb. 2022. tab
Article
in English
| LILACS
| ID: biblio-1365347
ABSTRACT
SUMMARY OBJECTIVE:
Beta-thalassemia minor is a blood disease caused by a hereditary decrease in beta-globin synthesis, frequently leading to hypochromic microcytic anemia. Formerly called endothelial cell-specific molecule 1, endocan is a proteoglycan released by vascular endothelial cells in many organs. Our aim was to investigate the relationship between the beta-thalassemia minor patients and the healthy control group in terms of serum endocan level.METHODS:
The study was performed in a total of 80 subjects. They were divided into two groups, the beta-thalassemia minor group (n=40) and the healthy control group (n=40). Serum endocan levels, age, sex, body mass index value, and tobacco use data of these groups were compared.RESULTS:
No statistically significant difference was detected between the two groups in terms of age, sex, and body mass index values (p>0.05). Endocan levels were measured to be 206.85±88.1 pg/mL in the beta-thalassemia minor group and 236.1±162.8 pg/mL in the control group with no significant difference between the groups in terms of serum endocan levels (p>0.05).CONCLUSIONS:
In our study, there was no change in endocan level in beta-thalassemia minor. This might be because serum endocan levels are affected by multi-factorial reasons. Serum endocan levels may be altered secondarily to decreased beta-globin chain, increased sympathetic activity due to anemia, or platelet dysfunction induced by oxidative stress in beta-thalassemia minor. Further multicenter studies involving more patients are necessary to demonstrate this.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Proteoglycans
/
Beta-Thalassemia
/
Neoplasm Proteins
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2022
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Bezmialem Vakif University/TR
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