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Drug utilization study in neonatal intensive care unit at tertiary care hospital
Namdarifar, Farshad; Raouf, Shahrzad; Shahraki, Emad Malekpour; Murthy, N.B. Sridhara.
  • Namdarifar, Farshad; Rajiv Gandhi University of Health Sciences. Oxbridge College of Pharmacy. Department of Pharmacy. Bangalore. IN
  • Raouf, Shahrzad; Rajiv Gandhi University of Health Sciences. Oxbridge College of Pharmacy. Department of Pharmacy. Bangalore. IN
  • Shahraki, Emad Malekpour; Rajiv Gandhi University of Health Sciences. Oxbridge College of Pharmacy. Department of Pharmacy. Bangalore. IN
  • Murthy, N.B. Sridhara; Rajiv Gandhi University of Health Sciences. Oxbridge College of Pharmacy. Department of Pharmacy. Bangalore. IN
Rev. Assoc. Med. Bras. (1992) ; 68(2): 212-216, Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365352
ABSTRACT
SUMMARY

OBJECTIVE:

Neonates are more susceptible to drug interactions and adverse effects, and special care should be taken when prescribing medication to them. This study aimed to investigate drug usage in the neonatal intensive care unit of a tertiary care hospital.

METHODS:

This prospective observational study was conducted on 98 patients at the Apollo tertiary care hospital (Bannerghatta, Bangalore, India) in a period of 6 months. The most common indications for neonatal intensive care unit admission, average number of drugs per patient, the most frequently used medication, distribution of patients based on the birth procedure, and possible drug interactions were collected from patient profiles.

RESULTS:

Among the patients, 52% were males and 48% were females. Notably, 38% of patients were preterm, 60% were term, and only 2% were post-term. Also, 80.6% were born by cesarean section and 19.4% were born by normal vaginal delivery. The highest mean of drug use was in the patient of 1,000-1,500 g (8.06 per patient). Preterm was the most frequent indication for admission in neonatal intensive care unit, followed by hyperbilirubinemia and then respiratory distress syndrome. The most frequently used medication was vitamin K (99%) and antibiotics followed by dextrose. In different types of antibiotics, amikacin (41%), cefoperazone+sulbactam (35%), cephalosporin (1%), ceftriaxone (0.7%), and amoxicillin (0.3%) were commonly administered. There were some possible interactions, such as aminoglycoside with furosemide and calcium gluconate.

CONCLUSION:

Premature birth and resulting low birth weight were the main reasons for drug prescription. High administration of antibiotics is probably an area of concern and should be seriously considered.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Intensive Care Units, Neonatal / Drug Utilization Type of study: Observational study Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2022 Type: Article Affiliation country: India Institution/Affiliation country: Rajiv Gandhi University of Health Sciences/IN

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Full text: Available Index: LILACS (Americas) Main subject: Intensive Care Units, Neonatal / Drug Utilization Type of study: Observational study Limits: Female / Humans / Male / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2022 Type: Article Affiliation country: India Institution/Affiliation country: Rajiv Gandhi University of Health Sciences/IN