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Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis
Albuquerque, Agnes Afrodite S; Celotto, Andrea Carla; Becari, Christiane; Prandi, Marelaine; Barbosa, Jessyca M; Moreira Neto, Francisco; Jordani, Maria Cecília; Evora, Paulo Roberto B.
  • Albuquerque, Agnes Afrodite S; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Celotto, Andrea Carla; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Becari, Christiane; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Prandi, Marelaine; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Barbosa, Jessyca M; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Moreira Neto, Francisco; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Jordani, Maria Cecília; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Evora, Paulo Roberto B; Universidade de São Paulo. Department of Surgery and Anatomy. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
Rev. bras. cir. cardiovasc ; 37(1): 20-28, Jan.-Feb. 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1365538
ABSTRACT
Abstract

Introduction:

There are many reasons to believe that the nitric oxide/guanosine 3'5' - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the investigation rationale.

Methods:

The IC (3mg/kg intravenous infusion) study protocol included five experimental groups; 1) Control group — saline was injected at 0 and 10 minutes; 2) IC group — IC was injected at 0 and saline at 10 minutes; 3) compound 48/80 (C48/80) group — C48/80 was injected at 0 minute and saline at 10 minutes; 4) C48/80 + IC group — C48/80 was injected at 0 minute and IC at 10 minutes; and 5) IC + C48/80 group — IC was injected at 0 minute and C48/80 at 10 minutes. The studies were carried out by registering and measuring hemodynamic and blood gasometric parameters, including continuous cardiac output.

Results:

1) The effects of the drugs (IC and C48/80) were more evident in the first 20 minutes of recording; 2) hypotensive responses were more pronounced in the C48/80 groups; 3) IC isolated or applied before C48/80 caused transient pulmonary hypertension; and 4) after the first 20 minutes, the pressure responses showed stability with apparent hypotension more pronounced in the C48/80 groups. Clinical observations showed significant hemodynamic instability and catastrophic anaphylactic reactions (agitation, pulmonary hypertension, severe bronchospasm, urticaria, high-intensity cyanosis, violent gastric hypersecretion, and ascites).

Conclusion:

A global results analysis showed differences between groups only in the first 20 minutes of the experiments.


Full text: Available Index: LILACS (Americas) Type of study: Practice guideline Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Type of study: Practice guideline Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR