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Análisis de inmunogenicidad y perfil de seguridad de vacunas contra el SARS-CoV-2 en ensayos clínicos de fase I/II / Immunogenicity and safety profile analysis of SARS-CoV-2 vaccines in phase I/II clinical trials
Moraga Véliz, Alfonso; Arenas Leyton, Diego; Manterola Maulén, Rocío; Álvarez Milanés, Alejandro.
Affiliation
  • Moraga Véliz, Alfonso; Hospital Regional de Talca. Servicio de Medicina. Talca. CL
  • Arenas Leyton, Diego; Universidad Católica del Maule. Facultad de Medicina. Talca. CL
  • Manterola Maulén, Rocío; Universidad Católica del Maule. Facultad de Medicina. Talca. CL
  • Álvarez Milanés, Alejandro; Universidad Católica del Maule. Facultad de Medicina. Talca. CL
Rev. méd. Maule ; 35(1): 18-24, oct. 2020. tab
Article in Es | LILACS | ID: biblio-1366379
Responsible library: CL1.1
ABSTRACT
The development of an effective vaccine against SARSCoV-2 has turned into a global priority in order to stop the advance of this ongoing COVID-19 pandemic. To date there are 25 candidate vaccines currently in a clinical trial stage, 3 of which have been subjected to phase I/II preliminary reports (ChAdOx1 nCoV-19, BNT162b1 and mRNA-1273). These vaccines have demonstrated to elicit robust cellular and humoral immune responses when compared to convalescent patients serum samples and have shown an acceptable safety profile with no reported severe side effects. Here we discuss the reported evidence regarding these vaccines.
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Full text: 1 Index: LILACS Main subject: Viral Vaccines / Pandemics / COVID-19 Type of study: Clinical_trials Limits: Humans Language: Es Journal: Rev. méd. Maule Journal subject: MEDICINA Year: 2020 Type: Article
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Full text: 1 Index: LILACS Main subject: Viral Vaccines / Pandemics / COVID-19 Type of study: Clinical_trials Limits: Humans Language: Es Journal: Rev. méd. Maule Journal subject: MEDICINA Year: 2020 Type: Article