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Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L. ) Skeels in Wistar rats
Moreira, Leise Nascimento; Santos, Jymmys Lopes dos; Souza, Lúcio Marques Vieira.
  • Moreira, Leise Nascimento; Universidade Federal de Sergipe. Departamento de Fisiologia. Laboratório de Química de Produtos Naturais e Bioquímica. São Cristóvão, SE. BR
  • Santos, Jymmys Lopes dos; Universidade Federal de Sergipe. Departamento de Fisiologia. Laboratório de Química de Produtos Naturais e Bioquímica. São Cristóvão, SE. BR
  • Souza, Lúcio Marques Vieira; Universidade Federal de Sergipe. Departamento de Fisiologia. Laboratório de Química de Produtos Naturais e Bioquímica. São Cristóvão, SE. BR
Acta sci., Health sci ; 43: e52931, Feb.11, 2021.
Article in English | LILACS | ID: biblio-1368486
ABSTRACT
Syzygiumcumini(L.) Skeels wasadaptedto the climatic conditionsandsoil typesin Brazil. Its fruits, leaves andinner barkare usedin folk medicinedue to their highantioxidant, anti-inflammatory, anticarcinogenicandantidiabeticactivities mainlyassociated with the presenceof phenolic compounds. It is estimated thatat least300million peopleworldwide developdiabetesand approximately 11million peopleare carriersof the disease in Brazil.The objectiveof this workwas to evaluate thein vitro antioxidant activity, as well as thehypoglycemic actionofhydroethanolic extract(HEE), the ethyl acetate(EAF) andhydromethanolic(HMF) fractions from leavesofS.cumini(L.) Skeels in rats. All assays werecarried out in three replications. Data wereexpressed as meanSDand significance was evaluated by ANOVAand Bonferronitest (p < 0.05). The results indicatea significant(p < 0.05) total phenolcontent (207 ± 2.3GAE mg g-1) andantioxidant activity(EC50=9.05±0.170 µg mL-1) for EAF. HEE and its fractions showed no significant (p > 0.05) actionto modulateglucosebytheOGTT assayinnondiabetic micecompared to control. Thus the use of the plant against diabetes in individuals is not proven.
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Full text: Available Index: LILACS (Americas) Main subject: Biological Products / Rats, Wistar / Syzygium / Hypoglycemic Agents / Antioxidants Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta sci., Health sci Journal subject: Medicina / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Sergipe/BR

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Full text: Available Index: LILACS (Americas) Main subject: Biological Products / Rats, Wistar / Syzygium / Hypoglycemic Agents / Antioxidants Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta sci., Health sci Journal subject: Medicina / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Sergipe/BR