Your browser doesn't support javascript.
loading
Morphological changes in leukocytes of acute SARS-CoV-2 infection patients, Amazon, Brazil / Alterações morfológicas em leucócitos de pacientes com infecção aguda por SARS-CoV-2, Amazônia, Brasil
Brito Junior, Lacy Cardoso de; Silva, Rayeli Thaisse Pinheiro da; Paixão, Ana Paula Silveira; Pereira, Vanessa Ingrid Cardoso; Ferreira, Roberta Isabella Senna; Gomes, Rafaelli de Souza.
  • Brito Junior, Lacy Cardoso de; Federal University of Pará. Belém. BR
  • Silva, Rayeli Thaisse Pinheiro da; Federal University of Pará. Belém. BR
  • Paixão, Ana Paula Silveira; Federal University of Pará. Belém. BR
  • Pereira, Vanessa Ingrid Cardoso; Federal University of Pará. Belém. BR
  • Ferreira, Roberta Isabella Senna; Federal University of Pará. Belém. BR
  • Gomes, Rafaelli de Souza; Federal University of Pará. Belém. BR
Article in English | LILACS | ID: biblio-1368616
RESUMO
RESUMO

Introdução:

A pandemia pelo novo coronavírus (SARS-CoV-2) trouxe muitas incertezas sobre quais parâmetros laboratoriais seriam mais adequados durante a evolução da COVID 19.

Objetivos:

Correlacionar os resultados do hemograma (HGM), da relação neutrófilos/linfócitos (R N/L), da proteína C reativa (PCR) e dos achados morfológicos de indivíduos diagnosticados com infecção por SARS-CoV-2 através de Reação em Cadeia da Polimerase em Tempo Real (RT-PCR) em um laboratório particular de Belém, Pará, no período de março a setembro de 2020.

Materiais e Métodos:

Estudo retrospectivo com 30 indivíduos, de ambos os sexos, qualquer idade e queixa clínica, de origem domiciliar ou hospitalar que realizaram HGM, PCR e RT-PCR para COVID 19 até o 8o dia de infecção. As alterações morfológicas foram analisadas após a seleção das lâminas desses pacientes.

Resultados:

Amostra composta por 15 homens e 15 mulheres, com idades entre 7 e 92 anos. Desses, 12/30 indivíduos estavam em domicílio e 18/30 internados. As principais queixas foram febre, mal-estar geral, diarreia e desconforto respiratório. O estudo estatístico mostrou a existência de relação de dependência direta entre os aumentos da R N/L, PCR e necessidade de internação (p=0,0005). A análise morfológica mostrou neutrófilos hipossegmentados com granulações tóxicas, monócitos vacuolizados e linfócitos reativos com citoplasma basofílico.

Conclusão:

Nossos resultados associam os níveis intermediários e elevados da R N/L com o aumento de PCR e a gravidade da doença, porém, sem relação com os achados morfológicos em neutrófilos, linfócitos e monócitos que foram comuns a todos os pacientes diagnosticados até o 8o dia de infecção. (AU)
ABSTRACT
ABSTRACT Morphological changes in leukocytes of acute SARS-CoV-2 infection patients, Amazon, BrazilORIGINAL ARTICLE

Introduction:

The pandemic for the new coronavirus (SARS-CoV-2) brought many uncertainties about which laboratory parameters would be most suitable during the evolution of COVID 19.

Objectives:

Correlate the results of the blood count (BC), the neutrophil/lymphocyte ratio (N/LR), the C-reactive protein (CRP) and morphological findings of individuals diagnosed with SARS-CoV-2 infection through Polymerase Chain Reaction in Real Time (RT-PCR) in a private laboratory in Belém, Pará, from March to September 2020. Materials and

Methods:

Retrospective study with 30 individuals, of both sexes, any age and clinical complaint, of home or hospital origin who underwent BC, CRP and RT-PCR for COVID 19 until the 8th day of infection. Morphological changes were analyzed after selecting the slides for these patients.

Results:

Sample composed of 15 men and 15 women, aged between 7 and 92 years. Of these 12/30 individuals were at home and 18/30 were hospitalized. The main complaints were fever, malaise, diarrhea and respiratory distress. The statistical study showed a direct dependency relationship between increases in N/LR, CRP and the need for hospitalization (p = 0.0005). Morphological analysis showed hyposegmented neutrophils with toxic granulations, vacuolated monocytes, and reactive lymphocytes with basophilic cytoplasm.

Conclusion:

Our results associate intermediate and elevated levels of N/LR with increased CRP and disease severity, however, unrelated to the morphological findings in neutrophils, lymphocytes and monocytes that were common to all patients diagnosed up to the 8th day of infection. (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Lymphocytes / Monocytes / Coronavirus Infections / Severe acute respiratory syndrome-related coronavirus / COVID-19 / Neutrophils Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Medicina (Ribeirao Preto, Online) Journal subject: Medicina Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pará/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Lymphocytes / Monocytes / Coronavirus Infections / Severe acute respiratory syndrome-related coronavirus / COVID-19 / Neutrophils Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Medicina (Ribeirao Preto, Online) Journal subject: Medicina Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pará/BR