Combinación de bardoxolona y DMF Mejora la isquemia cerebral/reperfusión Lesión en ratas macho / Combination of Bardoxolone and DMF Ameliorates Cerebral Ischemia / Reperfusion Injury in Male Rats
Prensa méd. argent
;
106(3): 191-201, 20200000. tab, fig
Article
in English
| LILACS, BINACIS
| ID: biblio-1369119
ABSTRACT
Background:
Ischemic stroke has been ranked as the second cause of death in patients worldwide. Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury. The present study aimed to investigate the effect of Berberine on cerebral I/R injury and the role of inflammation in this process. Material andMethods:
The study was carried out on 36 Wistar-albino rats, divided into four groups including Sham group, I/R group, I/R+ (control-vehicle DMSO) and I/R+ Berberine 5 mg/kg injected intraperitoneally 1 hour before induction of ischemia. Measurement of brain tissue IL-1ß, ICAM1, caspase-3, Notch 1 and Jagged 1 was done after one hour of reperfusion in addition to assessment of the brain infracted area and histopathological analysis.Results:
Berberine attenuates cerebral I/R injury induced increase in inflammatory cytokine (IL-1ß), adhesion molecule (ICAM-1) and proapoptotic enzyme (caspase-3). Additionally, it reduces the size of infracted area and histopathological damage; such protective effect could be mediated by Notch 1 signaling pathway since Berberine further unregulated the increased levels of Notch 1 and Jagged 1 seen in brain with I/R injury.Conclusions:
Berberine has a neurocytoprotective outcome against cerebral I/R injury which is manifested as anti-inflammatory anti-apoptotic effect that preserved cell structure and viability, in the meantime this effect could be mediated by Notch 1 signaling pathway.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Berberine
/
Reperfusion Injury
/
Brain Ischemia
/
Rats, Wistar
/
Caspase 1
/
Receptor, Notch1
/
Jagged-1 Protein
Limits:
Animals
Language:
English
Journal:
Prensa méd. argent
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Iraq
Institution/Affiliation country:
The Islamic University/IQ
/
University of Al-Qadisiyah/IQ
/
University of Kufa/IQ
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