Mechanism of dexmedetomidine preconditioning on spinal cord analgesia in rats with functional chronic visceral pain
Acta cir. bras
;
37(2): e370203, 2022. graf, ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1374068
ABSTRACT
Purpose:
To analyze the effect and mechanism of dexmedetomidine (DEX) analgesia pretreatment on functional chronic visceral pain in rats.Methods:
Rats were divided into six groups W1, W2, W3, W4, W5, and W6. The behavioral changes and electrophysiological indexes of rats in each group before and after DEX treatment were detected.Results:
The levels of abdominal withdrawal reflex (AWR) in W5 and W6 groups were significantly lower than those in group W3, while the levels of thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT) were significantly higher than those in group W3 (p < 0.05). The electromyographic signals of W1, W5, and W6 groups showed little fluctuation, while those of groups W2, W3, and W4 showed obvious fluctuation. TLR4 mRNA expression, IRF3, P65, and phosphorylation levels in W4, W5, and W6 groups were significantly lower than those in group W2 (p < 0.05).Conclusions:
Dexmedetomidine epidural anesthesia pretreatment could significantly inhibit visceral pain response in rats with functional chronic visceral pain, and its mechanism was related to the activation of TLR4 in spinal dorsal horn tissue of rats and the activation inhibition of IRF3 and P65 in the downstream key signals.Subject(s)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Dexmedetomidine
/
Toll-Like Receptor 4
/
Visceral Pain
/
Analgesia
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Year:
2022
Type:
Article
Institution/Affiliation country:
General Hospital of Southern Theatre Command/CN
/
Peoples Hospital of Guangxi Zhuang Autonomous Region/CN
/
Southern Medical University/CN
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