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Analysis of high-intensity interval training on bone mineral density in an experimental model of type 2 diabetes
Paiva, Letícia Alves; Silva, Iandara Schettert; Oliveira Júnior, Silvio Assis de; Souza, Albert Schiaveto de; Jacques, Claudio Osório Brito.
  • Paiva, Letícia Alves; Universidade Federal do Mato Grosso do Sul. Faculty of Medicine. Postgraduate Program in Health and Development. Campo Grande. BR
  • Silva, Iandara Schettert; Universidade Federal do Mato Grosso do Sul. Faculty of Medicine. Postgraduate Program in Health and Development. Campo Grande. BR
  • Oliveira Júnior, Silvio Assis de; Universidade Federal do Mato Grosso do Sul. Integrated Institute of Health. Postgraduate Program in Health and Development. Campo Grande. BR
  • Souza, Albert Schiaveto de; Universidade Federal do Mato Grosso do Sul. Biosciences Institute. Postgraduate Program in Health and Development. Campo Grande. BR
  • Jacques, Claudio Osório Brito; Universidade Federal do Mato Grosso do Sul. Faculty of Pharmaceutical Sciences. Research and Production Laboratory. Campo Grande. BR
Acta cir. bras ; 37(2): e370207, 2022. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1374069
ABSTRACT

Purpose:

To analyze the effect of high-intensity interval training (HIIT) on bone mineral density (BMD) in a model of type 2 diabetes mellitus.

Methods:

Thirty-two male, adult, 12-week-old rats (Rattus norvegicus), of the Wistar lineage, were used. The animals induced to the experimental model received a high fat diet for 10 days and, after that period, intraperitoneal injection of streptozotocin (40 mg·kg­1), dissolved in 20 mmol·L­1 sodium citrate solution (pH = 4.5). The experimental group of diabetes was formed by the animals that, 48 h after the injection of streptozotocin, had fasting blood glucose > 250 mg·dL­1). The animals were randomly divided into four groups with eight animals each HIIT experimental diabetes; HIIT control; sedentary experimental diabetes and sedentary control. The animals in the HIIT group performed an aerobic exercise protocol on a treadmill inclined at an angle of 15° to the horizontal, with interspersed intensity. Five weekly sessions, lasting 49 min each, were held for 6 weeks. The analysis of cortical bone density (CBD) and BMD were performed by X-ray images using the In-Vivo Xtreme II/Bruker system.

Results:

For CBD and BMD, when comparing diabetes and control groups, a significant difference was seen between groups in relation to HIIT (p = 0.007). Animals submitted and not submitted to HIIT in the same group showed a significant difference between groups in relation to diabetes (p < 0.001).

Conclusions:

The HIIT experimental diabetes group had increased CBD and BMD in comparison with the sedentary experimental diabetes group.

Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Bone Density / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / High-Intensity Interval Training Limits: Animals Language: English Journal: Acta cir. bras Year: 2022 Type: Article Institution/Affiliation country: Universidade Federal do Mato Grosso do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Bone Density / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / High-Intensity Interval Training Limits: Animals Language: English Journal: Acta cir. bras Year: 2022 Type: Article Institution/Affiliation country: Universidade Federal do Mato Grosso do Sul/BR