Solid Phase Extraction and Simultaneous Chromatographic Quantification of some Non-steroidal Anti-inflammatory Drug Residues; an Application in Pharmaceutical Industrial Wastewater Effluent
Braz. J. Pharm. Sci. (Online)
;
58: e18691, 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1374574
ABSTRACT
Abstract Two sensitive and selective methods were developed for the simultaneous determination of four commonly used non-steroidal anti-inflammatory drugs (NSAIDs), namely; paracetamol (PCM), diclofenac sodium (DCF), ibuprofen (IBP), and indomethacin (IND) in wastewater effluents. The first method used HPLC for the determination of the studied drugs using a mobile phase consisting of phosphate buffer (pH 3.0) and acetonitrile at a flow rate of 1 mL/min. in gradient elution mode and detection at 220 nm. The separation process was performed on BDS Hypersil Cyano column (250 x 4.6 mm, 5 µm). The second method was a TLC-densitometric one which was performed using n-Hexane ethyl acetate acetic acid in the ratio (63.50.5) as a developing system. The proposed chromatographic methods were successfully applied for the selective determination of the four studied drugs in simulated and real pharmaceutical wastewater samples after their solid-phase extraction
Full text:
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Index:
LILACS (Americas)
Main subject:
Industrial Effluents
/
Anti-Inflammatory Agents, Non-Steroidal
/
Drug Industry
/
Wastewater
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Type:
Article
Affiliation country:
Egypt
/
Saudi Arabia
Institution/Affiliation country:
Cairo University/EG
/
Future University/EG
/
Pharmaoverseas Company/EG
/
Prince Sattam Bin Abdul-Aziz University/SA
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