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Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health
Pereira, Luciano José; Andrade, Eric Francelino; Barroso, Lívia Corrêa; Lima, Renato Ribeiro de; Macari, Soraia; Paiva, Saul Martins; Silva, Tarcília Aparecida.
  • Pereira, Luciano José; Universidade Federal de Lavras - UFLA. Department of Health Sciences. Lavras. BR
  • Andrade, Eric Francelino; Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM. Department of Physiology. Unaí. BR
  • Barroso, Lívia Corrêa; Universidade Federal de Minas Gerais - UFMG. School of Dentistry. Department of Oral Pathology and Surgery. Belo Horizonte. BR
  • Lima, Renato Ribeiro de; Universidade Federal de Lavras - UFLA. Department of Exact Sciences. Lavras. BR
  • Macari, Soraia; Universidade Federal de Minas Gerais - UFMG. School of Dentistry. Department of Restortaive Dentistry. Belo Horizonte. BR
  • Paiva, Saul Martins; Universidade Federal de Minas Gerais - UFMG. School of Dentistry. Department of Paediatric Dentistry and Orthodontics. Belo Horizonte. BR
  • Silva, Tarcília Aparecida; Universidade Federal de Minas Gerais - UFMG. School of Dentistry. Department of Oral Pathology and Surgery. Belo Horizonte. BR
Braz. oral res. (Online) ; 36: e055, 2022. tab, graf
Article in English | LILACS-Express | LILACS, BBO | ID: biblio-1374742
ABSTRACT
Abstract Bone quality is an important issue in dentistry. Low bone density may be associated with more severe periodontitis, and may influence implant therapy success. Recent evidence suggests that physical activity can improve alveolar bone quality. Irisin is an exercise-mediated peptide that might be involved in this process. We assessed the effect of exercise and that of intra-peritoneal irisin administration on bone quality in healthy and osteoporosis-induced rodents. This study was registered at PROSPERO (CRD42020184140), and followed PRISMA guidelines. A search by two independent examiners was conducted in five databases and gray literature up to July 2021, without restrictions regarding language or date of publication. Initially, they analyzed retrieved titles and abstracts (n=3,844) based on eligibility criteria. Of this total, 19 studies remained for full-text reading, and 16 proceeded to the data extraction and quality assessment phases. Meta-analyses were conducted (n= 6 studies) to establish the effects of irisin administration on cancellous bone mineral density (BMD). Exercise or irisin administration enhanced bone quality, but the meta-analysis showed that BMD increased only slightly in osteoporotic rodents (BMD mean difference 0.03 mg/cm3 - 95% CI 0.01-0.05). This indicates that they had no significant benefits on the bones of healthy animals. Implications of key findings evidence the potential of irisin as an agent able to mitigate bone loss caused by osteoporosis, an outcome that could favor dental rehabilitation. More studies investigating the effect of irisin on alveolar bone are needed to elucidate its therapeutic viability and implications.


Full text: Available Index: LILACS (Americas) Type of study: Practice guideline / Systematic reviews Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Lavras - UFLA/BR / Universidade Federal de Minas Gerais - UFMG/BR / Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM/BR

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Full text: Available Index: LILACS (Americas) Type of study: Practice guideline / Systematic reviews Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Lavras - UFLA/BR / Universidade Federal de Minas Gerais - UFMG/BR / Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM/BR