Your browser doesn't support javascript.
loading
Differential protein expression of osteoclastogenic factors in odontogenic cysts and tumors
Almeida Junior, Vildeman Rodrigues de; Leite, Eder Gerardo Santos; Almeida, Marcus Vinicius; Castro, Jurema Freire Lisboa de; Freitas, Roseana de Almeida; Xavier, Flávia Caló Aquino; Figueiredo, Andreia Leal; Santos, Jean Nunes; Henriques, Águida Cristina Gomes.
  • Almeida Junior, Vildeman Rodrigues de; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
  • Leite, Eder Gerardo Santos; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
  • Almeida, Marcus Vinicius; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
  • Castro, Jurema Freire Lisboa de; Universidade Federal do Pernambuco. Department of Dentistry. Graduate Program in Oral Pathology. Recife. BR
  • Freitas, Roseana de Almeida; Universidade Federal do Rio Grande do Norte. Department of Dentistry. Graduate Program in Oral Pathology. Natal. BR
  • Xavier, Flávia Caló Aquino; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
  • Figueiredo, Andreia Leal; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
  • Santos, Jean Nunes; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
  • Henriques, Águida Cristina Gomes; Universidade Federal da Bahia. Graduate Program in Dentistry and Health. Salvador. BR
Braz. oral res. (Online) ; 36: e072, 2022. tab, graf
Article in English | LILACS-Express | LILACS, BBO | ID: biblio-1374758
ABSTRACT
Abstract The osteolytic activity of odontogenic cysts and tumors is directly associated with their growth and aggressiveness. The influence of proteins expressed by epithelial and mesenchymal cells on this biological event differs between indolent cystic lesions, aggressive cystic lesions, and odontogenic tumors. The objective of this study was to compare the immunohistochemical expression of factors that stimulate (receptor activator of nuclear factor kappa-Β ligand - RANKL, cathepsin K - CatK and matrix metallopeptidase 8 - MMP-8) and inhibit (osteoprotegerin - OPG) osteoclastogenesis between dentigerous cyst (DC), glandular odontogenic cyst (GOC), odontogenic keratocyst (OKC), and ameloblastoma (AB). Paraffin-embedded sections of nine DCs, nine GOCs, 20 OKCs, 21 ABs, and four dental follicles (DFs) were subjected to immunohistochemistry. Immunoreactivity was analyzed semiquantitatively and quantitatively in epithelium and connective tissue, respectively. The proteins were immunoexpressed in epithelial and mesenchymal cells of all lesions studied. The expression of RANKL and CatK was higher in OKC, AB, and GOC (p<0.005). Higher expression of OPG was found in DF and DC compared to the other markers (p<0.005). MMP-8 expression was high in GOC and OKC. This study demonstrated the differential expression of factors that inhibit and stimulate bone resorption during the development of DC, GOC, OKC, and AB. Higher expression of RANKL and CatK was observed in more aggressive lesions. OPG appears to be one of the molecules responsible for the slower growth of DC.


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Bahia/BR / Universidade Federal do Pernambuco/BR / Universidade Federal do Rio Grande do Norte/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Bahia/BR / Universidade Federal do Pernambuco/BR / Universidade Federal do Rio Grande do Norte/BR