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Immunohistochemical study of the plasminogen activator system in benign epithelial odontogenic lesions
Costa, Carla Samily de Oliveira; Mafra, Rodrigo Porpino; Rolim, Larissa Santos Amaral; Souza, Lélia Batista de; Pinto, Leão Pereira.
  • Costa, Carla Samily de Oliveira; Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
  • Mafra, Rodrigo Porpino; Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
  • Rolim, Larissa Santos Amaral; Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
  • Souza, Lélia Batista de; Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
  • Pinto, Leão Pereira; Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
Braz. oral res. (Online) ; 36: e071, 2022. tab, graf
Article in English | LILACS-Express | LILACS, BBO | ID: biblio-1374759
ABSTRACT
Abstract The aim of this study was to analyze and compare the immunohistochemical expression of plasminogen activator system (PAS) proteins (uPA, uPAR, and PAI-1) in ameloblastomas (AMBs), odontogenic keratocysts (OKCs), and dental follicles (DFs) representing normal odontogenic tissue, as well as to investigate possible correlations between these proteins. Twenty AMBs, 20 OKCs, and 10 DFs were selected for immunohistochemical analysis. In each case, the immunoexpression of uPA, uPAR, and PAI-1 was evaluated semiquantitatively based on the percentage of positivity in odontogenic epithelial and connective tissue cells. The epithelial immunoexpression of uPA was significantly lower in AMBs when compared to OKCs (p = 0.001) and DFs (p = 0.029). Significantly higher epithelial immunostaining for uPAR was observed in AMBs when compared to OKCs (p < 0.001). There were no significant differences in the epithelial immunoexpression of PAI-1 between AMBs and OKCs (p = 1.000). The correlations found for the expression of the studied proteins were not statistically significant (p > 0.05). However, the epithelial and connective tissue expressions of uPAR have a strong positive and statistically significant correlation in AMBs. The present results suggest that uPA is involved in the pathogenesis of OKCs and that uPAR may participate in tumorigenesis in AMBs. The high percentage of PAI-1-positive cells suggests a possible role for this protein in the development of AMBs and OKCs. Furthermore, the studied proteins do not seem to act synergistically in AMBs, OKCs, and DFs.


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Norte/BR

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Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Norte/BR