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Dermatitis herpetiforme: manifestación específica de la enfermedad celiaca / Dermatitis herpetiformis: specific manifestation of celiac disease
Correa-Parra, Laura; Villa-Saldarriaga, María Paulina; Forero-Saldarriaga, Santiago.
  • Correa-Parra, Laura; Coomsocial IPS. Medellín. CO
  • Villa-Saldarriaga, María Paulina; Home Group SAS. Medellín. CO
  • Forero-Saldarriaga, Santiago; Fundación Universitaria Sanitas. Bogotá. CO
CES med ; 35(3): 272-283, sep.-dic. 2021. tab, graf
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1374768
RESUMEN
Resumen La enfermedad celíaca es un trastorno sistémico con base autoinmune, secundario a la exposición continua al gluten en personas con susceptibilidad genética, que lleva a desarrollo de anticuerpos específicos, afectando principalmente el intestino delgado con la subsecuente enteropatía. Las manifestaciones clínicas incluyen síntomas digestivos y manifestaciones extra intestinales. En este último grupo se destacan las manifestaciones dermatológicas, específicamente la dermatitis herpetiforme, la cual es considerada específica de la enfermedad celíaca. Clínicamente, se presenta como un exantema papulovesicular pruriginoso. El diagnóstico se basa en la biopsia de piel con inmunofluorescencia directa y la presencia de anticuerpos anti-transglutaminasa tisular 2 y solo en casos específicos se debe complementar con otros estudios. El tratamiento se basa en dieta libre de gluten, que mejora la sintomatología, controla y previene las complicaciones de la enfermedad celíaca, como las neoplasias digestivas y el desarrollo de otras enfermedades autoinmunes.
ABSTRACT
Abstract Celiac disease is a systemic disorder with an autoimmune basis, secondary to continuous exposure to gluten in people with genetic susceptibility, which leads to the development of specific antibodies mainly affecting the small intestine with subsequent enteropathy. The clinical manifestations include digestive symptoms and extra intestinal manifestations. In this last group, the dermatological manifestations stand out, specifically dermatitis herpetiformis, which is considered specific to Celiac disease. It presents clinically as a pruritic papulovesicular rash. The diagnosis is based on a skin biopsy with direct immunofluorescence and the presence of anti-tissue transglutaminase 2 antibodies, only in specific cases it should be complemented with other studies. Treatment is based on a gluten-free diet, which improves symptoms, controls and prevents complications of Celiac disease, such as digestive neoplasms and the development of other autoimmune diseases.


Full text: Available Index: LILACS (Americas) Language: Spanish Journal: CES med Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Colombia Institution/Affiliation country: Coomsocial IPS/CO / Fundación Universitaria Sanitas/CO / Home Group SAS/CO

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Full text: Available Index: LILACS (Americas) Language: Spanish Journal: CES med Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Colombia Institution/Affiliation country: Coomsocial IPS/CO / Fundación Universitaria Sanitas/CO / Home Group SAS/CO